J Bone Joint Surg Am. 2025 Apr 24. doi: 10.2106/JBJS.25.00101. Online ahead of print.

NO ABSTRACT

PMID:40273198 | DOI:10.2106/JBJS.25.00101

Injury. 2025 Apr 17:112306. doi: 10.1016/j.injury.2025.112306. Online ahead of print.

ABSTRACT

BACKGROUND: The popularity of electric bicycles (E-bikes) in The Netherlands has surged in recent years. Simultaneously, bicycle-related traffic injuries in The Netherlands have reached record levels. Given the significant societal and individual impact of traumatic brain injury (TBI) we investigated the relationship between E-bike usage and the occurrence of severe TBI.

METHODS: All bicycle crash victims aged twelve years and older admitted to the Isala Hospital from 1 January 2018 to 31 December 2022, were included from the National Trauma Registry. Data on bicycle type, anticoagulants, alcohol intoxication, and helmet use, was obtained from the hospitals' electronic patient record. The primary outcome variable was severe TBI verified on CT- or MRI-imaging. The secondary outcome variable was a skull fracture verified on X-ray or CT-imaging. Adjusted odds ratios (ORs) and 95 %-confidence intervals (CIs) were calculated using multivariable binary logistic regression analyses, adjusting for the risk factors alcohol intoxication, anticoagulant use, not wearing a helmet, health status before the accident, age and gender.

RESULTS: From 1 January 2018 to 31 December 2022, a total of 1878 patients were admitted following a bicycle crash. This group consisted of 1359 (73.4 %) regular cyclists and 519 (27.6 %) E-bikers. Multivariable regression analyses resulted in an OR of 1.64 (CI 1.20-2.22) for severe TBI and an OR of 1.50 (CI 1.08-2.08) for skull fractures.

CONCLUSION: In our study sample, E-bike usage was found to be an independent predictor for severe traumatic brain injury and skull fractures following a bicycle crash.

PMID:40268590 | DOI:10.1016/j.injury.2025.112306

Injury. 2025 Apr 15;56(6):112345. doi: 10.1016/j.injury.2025.112345. Online ahead of print.

ABSTRACT

INTRODUCTION: Describing surgical wounds accurately poses challenges due to the diverse terminology used for complications. Existing evaluation methods do not cater specifically to surgical wounds from post-ankle fracture surgery with osteosynthesis. Given the unique anatomical challenges and treatment considerations (limited tissue coverage and blood supply as well as the surgical treatment with osteosynthesis), a targeted wound score is essential for ensuring consistent evaluation and high-quality care and thereby optimizing patient outcomes and satisfaction. The study aimed to develop a wound score specifically for evaluating surgical wounds following ankle fracture surgery.

METHOD: Development of the Wound after Osteosynthesis Kolding score (WOK) proceeded through three phases: 1) identifying WOK domains, 2) developing item and response options, and 3) pilot testing the WOK score.

RESULTS: Five domains were identified: erythema, swelling, dehiscence, exudate and warmth. Response options were derived from literature and clinical insights. Content validity was assessed with an S-CVI/Ave of 0.93 for nurses and 0.82 for orthopedic surgeons. Orthopedic surgeons perceived erythema and warmth as less relevant, while nurses considered all five domains to be fairly or very relevant. High agreement between scores was found, but varying kappa scores were observed when assessing intra-rater reliability. Inter-rater reliability was acceptable across all domains (κ = 0.44 to 1.00). Warmth was omitted from the final WOK score due to low content validity among orthopedic surgeons and poor inter-rater reliability. Additionally, assessing warmth in a clinical setting was challenging because ankle brace stabilization affects overall skin humidity and warmth.

CONCLUSIONS: The Wound after Osteosynthesis Kolding score (WOK) has proven to be a content-valid and reliable tool for assessing minor complications in surgical wounds following ankle fracture surgery.

PMID:40267859 | DOI:10.1016/j.injury.2025.112345

Injury. 2025 Apr 17;56(6):112354. doi: 10.1016/j.injury.2025.112354. Online ahead of print.

ABSTRACT

History - A 38yo man was injured in a rugby match. He suffered an isolated, Achilles tendon rupture. He immediately went to his local emergency department. He was keen on the best treatment so that he could get back into playing rugby with his community team. Past Medical History and Social History - He was a married man and lived with his wife. He was a nonsmoker. He had no medical problems that he saw a physician about. He worked as an executive with an oil company and was also involved in many sports year-round. He had had surgery for previous sports related broken bones with no complications. He had no allergies and took no medications. He was a regular beer drinker after sports matches.

PMID:40267858 | DOI:10.1016/j.injury.2025.112354

Injury. 2025 Apr 12;56(6):112338. doi: 10.1016/j.injury.2025.112338. Online ahead of print.

ABSTRACT

BACKGROUND: This study aimed to investigate the outcomes of fasciotomy, including infection, amputation, and complications, in patients with crush injuries from the 2023 Turkey-Syria earthquake.

MATERIAL AND METHODS: Out of 210 patients presenting from the earthquake zone, 46 patients (23 male-23 female, mean age: 21 years) who underwent 52 extremity fasciotomies were included. Data collected included infection rates, need for grafts/flaps, amputation rates, creatinine, CK levels, need for dialysis, and neurologic injuries. Early fasciotomy was defined as ≤12 h and late as >12 h after the earthquake. Patients were categorized by fasciotomy timing and location (earthquake-zone or university hospital). Time to first debridement was also evaluated.

RESULTS: The median time to fasciotomy was 24 h (2-97 h, (IQR 12.5-65)). Fasciotomies performed in the earthquake zone had a higher infection rate (68 % vs. 25 %, p = 0.061), though this difference was not statistically significant, likely due to the small sample size. There was no significant difference in infection rates between patients who underwent early fasciotomy (8/13, 62 %) and those who underwent late fasciotomy (20/33, 61 %) (p = 1.0).Amputation was required in 7/46 patients (15 %), with 1/13 patient (8 %) in the early fasciotomy group and 6/33 patients (18 %) in the late fasciotomy group (p = 0.698). Skin grafting was performed for wound closure in 19 patients (42 %). In patients undergoing early fasciotomy, 75 % (9/12) required skin grafts for wound closure, whereas the rate in the late fasciotomy group was significantly lower at 30 % (10/33) (p = 0.019). The mean time to first debridement was significantly higher in infected patients [65.5 (SD 11.8) vs 57.8 (SD 11.4 h), p = 0034]. For wounds that required skin grafts, the average duration between the fasciotomy and initial debridement was significantly higher (68.5 vs 54 h), p = 0.001.

CONCLUSION: Fasciotomies performed in earthquake zones had higher infection rates compared to hospitals, though not statistically significant. Infections with potentially multi-drug resistant bacterias may increase the risk of complications like amputations. Timely debridement and efficient patient transfer remain essential to minimizing risks and improving outcomes.

PMID:40267857 | DOI:10.1016/j.injury.2025.112338

Int Orthop. 2025 Apr 23. doi: 10.1007/s00264-025-06535-y. Online ahead of print.

NO ABSTRACT

PMID:40266313 | DOI:10.1007/s00264-025-06535-y

Int Orthop. 2025 Apr 23. doi: 10.1007/s00264-025-06525-0. Online ahead of print.

ABSTRACT

PURPOSE: To assess long term survivorship, patient reported (PROMs) and radiological outcomes, and rate of adverse events and hardware removal after lateral closing wedge high tibial osteotomy (CWHTO) for the treatment of medial knee osteoarthritis (OA) and varus malalignment.

METHODS: Retrospective analysis of patients who underwent isolated CWHTO for medial OA in varus knee between 2009 and 2019 at the same institution was performed. Surgical failure was defined as conversion to total knee arthroplasty (TKA) or need for osteotomy revision procedure for varus recurrence, while clinical failure was defined by a Lysholm score under 65 points. Lysholm score, Visual Analogue Scale for pain (VAS), and patients' satisfaction with the treatment were evaluated. Radiographic parameters assessed included OA degree with the Kellgren Lawrence scale (KL), hip-knee-ankle angle (HKA), medial proximal tibial angle (MPTA), lateral distal femoral angle (LDFA), joint line convergence angle (JLCA), and posterior tibial slope (PTS). Adverse events and rate of hardware removal procedures were recorded through follow up visits and clinical records. Survival analysis was conducted through Kaplan-Meier method with surgical and clinical failure as endpoints.

RESULTS: 70 knees (mean age at surgery 43.3 years) were included in the survivorship analysis at a mean follow up of 11.6 ± 3.4 years. A failure rate of 12.85% (9/70) was recorded during the follow up period, with a survivorship of 92% and 75% at ten and 15 years of follow up, respectively. Mean Lysholm score and VAS at follow up were above the PASS threshold reported in literature. The 75.7% of patients were satisfied with the treatment. Radiological follow up indicated a residual mechanical varus of 2.1°, a decrease of 0.7° of intra articular deformity (JLCA), no change in PTS nor in KL index. The adverse events rate recorded was 5.7% (4/70). In nine knees (14.7%) among the patients survived from surgical failure a subsequent hardware removal procedure was performed.

CONCLUSION: CWHTO represents a safe procedure, which resulted in high survivorship (92% and 75% at ten and 15 years follow up, respectively), with satisfactory PROMs and radiological outcomes at long term follow up in patients affected by medial OA and varus malalignment.

LEVEL OF EVIDENCE: 5, Case Series.

PMID:40266312 | DOI:10.1007/s00264-025-06525-0

Int Orthop. 2025 Apr 23. doi: 10.1007/s00264-025-06542-z. Online ahead of print.

ABSTRACT

PURPOSE: To evaluate the efficacy of acellular hyaluronic acid matrix scaffold, BMAC, and autologous bone graft in providing biomechanical support and optimal microenvironment for OLTs treatment.

METHODS: A retrospective analysis of 81 ankles from 80 patients treated between 2018 and 2021 was conducted. The inclusion criteria included patients who underwent surgery for osteochondral lesions of the talus (OLTs) and received acellular hyaluronic acid matrix scaffold, bone marrow aspirate concentrate (BMAC) fibrin glue, and autologous bone graft. The exclusion criteria included prior ankle surgery, concurrent lateral instability surgery, malignancy, metabolic bone disease, or related medication. Clinical outcomes were assessed with FAOS, VAS, and SF-36 at a minimum of two years postoperatively. MRI findings were evaluated preoperatively, at six months, and 24 months postoperatively via MOCART. Subgroups were formed on the basis of age (< 45 vs. ≥45), BMI, and full weight bearing mobilization (FWBM) timing (4, 5, 6, or > 6 weeks).

RESULTS: Postoperative FAOS and SF-36 scores significantly improved (p = 0.000), whereas VAS scores decreased (p = 0.001). Early FWBM (4th week) was associated with superior FAOS, SF-36, and MOCART scores at 24 months (p = 0.039). Underweight and healthy individuals exhibited lower VAS (p = 0.001) and higher SF-36 scores (p = 0.000) at three months, alongside higher MOCART scores at 24 months compared to overweight patients (p = 0.039).

CONCLUSIONS: This study highlights the importance of a tailored approach to optimize the microenvironment and biomechanical support in OLTs treatment. Further research is required to refine therapeutic strategies.

PMID:40266311 | DOI:10.1007/s00264-025-06542-z

Int Orthop. 2025 Apr 23. doi: 10.1007/s00264-025-06523-2. Online ahead of print.

ABSTRACT

PURPOSE: This study aimed to evaluate the early clinical and radiological outcomes of robot assisted total knee arthroplasty, and to determine the efficiency and safety of its bone resection and implant positioning of the novel robot system.

METHODS: 144 patients who underwent primary TKA were enrolled in this prospective, multicenter RCT conducted in three hospitals. five patients were lost to follow-up at six weeks after surgery. Therefore, 139 patients (73 in the RA TKA group and 66 in the CI TKA group) remained in the final analysis. The primary outcome was the rate of patients whose postoperative alignment was less than 3° deviated from the planned evaluated by full-length weight-bearing X-rays of the lower limb at 12 weeks postoperatively. Secondary outcomes included coronal and sagittal alignment of the components, operation times, blood loss, 12-week range of motion(ROM), 12-week postoperative functional outcomes and satisfaction evaluated by the American Knee Society Score (KSS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and adverse events (AEs).

RESULTS: At 12 weeks postoperatively, we found the rate of radiographic inliers was significantly higher in the RA TKA group (90.4% vs. 59.1%; p < 0.05). The difference between planned and postoperative frontal femoral component (FFC) angle, frontal tibia component (FTC) angle and lateral femoral component (LFC) angle are significantly smaller in the RA TKA group (p < 0.05). The operation time was significantly longer in the RA TKA group than in the CI TKA group (133.01 vs. 92.33 min; p < 0.05). There was no significant difference in blood loss, 12-week ROM, 12-week postoperative functional outcomes and satisfaction evaluated by KSS and WOMAC scores. There were no AEs or SAEs that were determined to be "related" to the robotic system.

CONCLUSION: The novel robot assisted TKA is safe and more precise in bone resection and implant positioning as demonstrated in this trial.

PMID:40266310 | DOI:10.1007/s00264-025-06523-2

Injury. 2025 Apr 14:112344. doi: 10.1016/j.injury.2025.112344. Online ahead of print.

ABSTRACT

INTRODUCTION: Adverse Childhood Experiences (ACEs), such as violence exposure, are linked with numerous long-term health consequences. Adult firearm and other injury survivors presenting to level I trauma centers frequently report having youth family members exposed to firearm violence and other traumatic life events. Few investigations have examined the demographic and familial characteristics, or cumulative trauma burden of exposed family members.

METHODS: The investigation was a secondary analysis of data collected as part of a 25-site national US level I trauma center randomized clinical trial (N = 635). Baseline characteristics of firearm injury survivors (n = 128) versus all other injury survivors (n = 507) were compared, including number of children, pre-injury trauma history, and post-admission recurrent traumatic and stressful life events. Analyses were conducted on baseline characteristics of firearm injury survivors, including trauma history, and compared to non-firearm injury survivors. For injury survivors with children, mixed model regression was used to assess whether firearm injury was independently associated with an increased risk of childhood injury leading to hospitalization over the course of the year after the index parental injury admission.

RESULTS: There were few demographic and clinical differences between firearm and non-firearm injury survivors. Approximately 70% of adult injury survivors had at least one child. Over 10% of adult injury survivors had a child hospitalized in the year after the index admission; firearm injury survivors were no more likely than all other injury survivors to have a child hospitalized after the index admission. For injury survivors with children, mixed model regression analyses revealed a significant association between pre-injury childhood exposure to life-threating illness/injury and child injury hospitalization in the year after the index parental injury admission (Relative Risk = 1.92, 95% Confidence Interval = 1.08, 3.42).

CONCLUSIONS: Over 10% of adult injury survivors reported that their children were hospitalized for an injury in the year after an index injury admission. Prehospital childhood illness or injury admission was significantly associated with childhood injury hospitalization in the year after parental injury. Trauma centers could be harnessed as a public health point-of-contact for screening, intervention, and referral of ACEs, such as childhood injury.

PMID:40263031 | DOI:10.1016/j.injury.2025.112344

Injury. 2025 Apr 8;56(6):112315. doi: 10.1016/j.injury.2025.112315. Online ahead of print.

ABSTRACT

AIMS: In an increasingly frail population, simultaneous "fix and replace" surgery (fixation of the acetabulum to accommodate a press fit cup and total hip arthroplasty (THA)) is a novel alternative to open reduction and internal fixation (ORIF) alone in the management of acetabular fractures. We aimed to determine whether patients managed with "fix and replace" have comparable survivorship to those undergoing staged THA following previous open reduction and internal fixation for acetabular fracture.

METHODS: All Patients with acetabular fractures surgically managed within our Tertiary centre over a five year period (01/01/2018-30/05/2023) were identified. Thirty-four patients underwent simultaneous "fix and replace" surgery and 133 underwent acetabular ORIF alone. Twenty-one of these patients required staged THA (6 %).

RESULTS: Follow up mean was 2.7 years (SD ±1.7) for 'fix and replace' versus 3.3 years (SD ± 1.5) for staged THA. There was no statistically significant difference between the two groups with regards to BMI or sex. The fix and replace group were older (p = 0.001), had higher American Society of Anesthesiologists (ASA) grade (p = 0.006) and Charlson Comorbidity Index (CCI) (p = 0.027), respectively. High energy mechanism of injury accounted for 56 % of the "fix and replace" group compared to 48 % in the ORIF to THA. 74 % of 'fix and replace' were associated/complex fractures (LeTournel) compared to 53 % of staged THA. Mean wait to surgery was 3 days in the 'fix and replace' group compared to 186 days from listing to operation in the staged THA group. Survival analysis demonstrated acceptable results for both groups with greater than 85 % survival at 2 years and no statistical significantly worse survivorship in the 'fix and replace' group (p = 0.13). Complications were comparable in both groups (41 % versus 43 %, p = 0.58).

CONCLUSIONS: 'Fix and replace' is a good option for the elderly, co-morbid patient. It enables early weight bearing and has acceptable survivorship compared to staged THA following acetabular ORIF.

PMID:40262410 | DOI:10.1016/j.injury.2025.112315

J Bone Joint Surg Am. 2025 Apr 22. doi: 10.2106/JBJS.24.00248. Online ahead of print.

ABSTRACT

BACKGROUND: We previously established a small animal model of femoral head-neck cam-type hip deformity by inducing physeal injury in immature rabbits. We investigated whether this induced deformity led to hip osteoarthritis (OA) within 4 months.

METHODS: Six-week-old immature New Zealand White rabbits underwent surgery to induce physeal injury in the right femoral head, causing growth arrest and secondary head-neck deformity. Animals were divided into early-pre-OA (4 weeks) and late-OA (16 weeks) groups. Left hips served as (nonsurgical) controls. Radiographs were made to visualize deformities and OA progression. The Beck classification was used to assess macroscopic cartilage damage and OA on the acetabulum and femoral head. Micro-computed tomography (CT), histological scoring, and gene expression were used to evaluate OA progression. The Wilcoxon signed-rank test was used for group comparisons. Significance was set at p < 0.05.

RESULTS: At 16 weeks, the injured hips showed radiographic evidence of joint space narrowing and a higher OA grade than the control hips (p = 0.0002). Micro-CT confirmed degenerative OA changes and a higher femoral head bone volume fraction (BV/TV) and trabecular thickness (Tb.Th) in the injured hips than in the control hips (BV/TV: p = 0.0001, Tb.Th: p = 0.0007). Macroscopically, the injured hips exhibited a greater prevalence and severity of chondral lesions at 4 weeks (83.3%, p = 0.015) and 16 weeks (100.0%, p = 0.002) post-injury compared with the control hips (0%), with worsening over time (4 versus 16 weeks: p = 0.016). The Osteoarthritis Research Society International (OARSI) score and synovitis score increased from 4 to 16 weeks post-injury. Compared with the control hips, the injured hips showed decreased Col2 expression and increased Col10 and MMP13 expression at 16 weeks post-injury (p = 0.062, p = 0.016, p = 0.041, respectively), confirming catabolism and OA progression.

CONCLUSIONS: To our knowledge, we have created the first small animal model of hip OA secondary to experimentally induced head-neck deformity. In this model, the deformity resulted in hip OA at 16 weeks post-injury.

CLINICAL RELEVANCE: This model can be used to test future interventional therapies and study mechanisms of femoroacetabular impingement-mediated hip OA.

PMID:40261969 | DOI:10.2106/JBJS.24.00248

Int Orthop. 2025 Apr 22. doi: 10.1007/s00264-025-06543-y. Online ahead of print.

NO ABSTRACT

PMID:40261340 | DOI:10.1007/s00264-025-06543-y

Int Orthop. 2025 Apr 22. doi: 10.1007/s00264-025-06538-9. Online ahead of print.

NO ABSTRACT

PMID:40261339 | DOI:10.1007/s00264-025-06538-9

Int Orthop. 2025 Apr 22. doi: 10.1007/s00264-025-06540-1. Online ahead of print.

ABSTRACT

PURPOSE: Spondylodiscitis is a serious infection of the intervertebral discs and vertebrae, with rising incidence. This study provides an updated evaluation by analyzing causative microorganisms in tuberculous (TS), brucellar (BS), and pyogenic spondylodiscitis (PS). Our findings offer contemporary data to enhance understanding and management of spondylodiscitis.

METHODS: This retrospective study included 109 adult patients diagnosed with spondylodiscitis between 2011 and 2021 at a tertiary research center. Patients were categorized into three groups based on the causative pathogen. Demographic data, clinical presentations, laboratory findings, radiological imaging, and microbiological results were analyzed.

RESULTS: Among 109 patients, 59 (54.1%) had PS, 33 (32%) BS, and 17 (15.5%) TS. The cohort included 65 males (59.6%) and 44 females (40.4%), with a mean age of 57.6 ± 13.8 years. Back pain was the most common symptom (85.3%). Night sweats were more prevalent in BS (p < 0.001), while weight loss was less frequent in PS (p < 0.05). Diabetes was more common in PS (p < 0.001). PS cases had higher inflammatory markers (p < 0.001). Blood culture positivity was 53.6% in BS and 53.8% in PS. Surgery with tissue sampling was performed in 62 cases (56.9%). S. aureus was the most frequent pathogen, followed by Brucella spp.

CONCLUSION: Spondylodiscitis requires a multidisciplinary diagnostic approach due to its variable clinical presentations. PS is characterized by elevated inflammatory markers and concurrent infectious foci, BS by endemic risk factors and systemic symptoms, and TS by prolonged symptoms and thoracic involvement.

PMID:40261338 | DOI:10.1007/s00264-025-06540-1

Int Orthop. 2025 Apr 22. doi: 10.1007/s00264-025-06541-0. Online ahead of print.

ABSTRACT

Surgical approaches in bone surgery have undergone a long evolution over more than 130 years. While a number of publications have been devoted to the history of internal fixation, surgical approaches have remained neglected from this perspective. The development of approaches in musculoskeletal surgery is inextricably linked to four personalities. Theodor Kocher, in 1892, pointed out that descriptions of surgical approaches must be an essential part of surgical textbooks of operative techniques; James Edwin Thompson, in 1918, formulated the basic requirements for the surgical approaches to the skeleton of limbs; Arnold Kirkpatrick Henry published the first textbook of surgical approaches in 1927 and presented the concept of internervous planes in 1945; in the same year, Toufick Nicola created the first comprehensive atlas of surgical approaches to bones and joints of limbs, the pelvis and spine.

PMID:40261337 | DOI:10.1007/s00264-025-06541-0

Int Orthop. 2025 Apr 21. doi: 10.1007/s00264-025-06532-1. Online ahead of print.

ABSTRACT

PURPOSE: Implant wastage in trauma and orthopaedic (T&O) surgery remains an under-reported yet significant issue, contributing to rising healthcare costs and environmental concerns. With increasing surgical demand driven by an ageing population and the growing prevalence of conditions like osteoporosis, this study aimed to quantify implant wastage in T&O procedures at a Level 1 Major Trauma Centre in London, assessing both its frequency and financial impact.

METHODS: A retrospective cohort study was conducted on all weekday T&O procedures performed between 1st December 2023 and 31st January 2024. Two of the authors identified wasted implants using intraoperative implant logbooks, and cross-referencing implant stickers with post-operative radiographs. Data pertaining to patient demographics, procedure types, surgical sites, and implant usage were collected. Cost analysis was performed using procurement data to determine the financial impact of implant wastage.

RESULTS: Among 184 procedures analysed, 131 (71.2%) used implants, with wastage observed in 108 (82.4%) cases. A total of 141 implants were wasted, with screws accounting for 92.9% (n = 131) of wasted implants. Locking screws were the most frequently discarded (n = 65; 46.1%). Across ORIF and intramedullary nailing procedures, an overall screw wastage rate of 20% (17-31%) was observed with 2.4 screws wasted per trauma procedure. The financial cost of implant wastage over the 44-day study period amounted to approximately £335 per day and £136 per case.

CONCLUSION: This study highlights the substantial economic burden associated with implant wastage in T&O surgery, with screws, particularly locking screws, being the primary contributors. Targeted interventions, including improved preoperative planning, precision-based implant selection, and enhanced intraoperative decision-making, are essential to reducing waste and improving cost-efficiency and sustainability in surgical practices. Further research should explore the broader economic and environmental impact of implant wastage, incorporating factors such as operative time and carbon footprint to develop comprehensive waste-reduction strategies.

LEVEL OF EVIDENCE: IV.

PMID:40257588 | DOI:10.1007/s00264-025-06532-1

Int Orthop. 2025 Apr 21. doi: 10.1007/s00264-025-06534-z. Online ahead of print.

ABSTRACT

PURPOSE: There is still a debate regarding the removal of the femoral stem due to the risk of trunnion. To answer this question, we conducted a study to compare long terms outcomes of isolated acetabular to total revision of MoM THA using an institutional arthroplasty registry.

METHODS: From 1996 to 2019, 150 patients (12.5%) of the 1202 revision THAs (rTHA) recorded in Geneva Arthroplasty Registry (GAR) underwent a revision of a MoM THA. After matching the two groups,126 patients were finally included: 63 in each group. The mean age was 64.4 (SD 11.6) years, 48.4% (61/126) were women with a mean BMI of 27.2 (SD 5.5) Kg/m2.

RESULTS: The overall survival rate was 88.1% [79.9-97.2%] at ten years. 10-year survival rate was 93.5% [86.2-100.0%] after isolated acetabular rTHA and 79.5% [61.7-100.0%] after total rTHA (p = 0.16). Regarding Hip Harris score and Merle d'Aubigne score, no difference at last follow-up was observed between the two groups (respectively: p = 0.39; p = 0.33). Regarding the chrome, cobalt, and nickel level reduction, no difference was observed between the two groups (respectively, p = 0.38, 0.81 and 0.97).

CONCLUSION: No difference was observed between isolated acetabular and total revision of MoM THAs regarding survival rate and ions levels at long term. It seems advisable to perform an isolated acetabular revision of a MoM THA when it is indicated.

LEVELS OF EVIDENCE: Level III, case control studies.

PMID:40257587 | DOI:10.1007/s00264-025-06534-z

Int Orthop. 2025 Apr 21. doi: 10.1007/s00264-025-06533-0. Online ahead of print.

ABSTRACT

PURPOSE: There is a paucity of clinical studies examining outcomes following surgical revision in cases of histologically confirmed arthrofibrosis after total hip arthroplasty (THA). Consequently, the aim of this study is to present the clinical outcomes and to identify risk factors for poor clinical and functional outcome following surgical intervention for histologically confirmed arthrofibrosis following THA.

METHODS: This study included 51 patients (51 hips) with histologically confirmed arthrofibrosis of the hip based on the synovial-like interface membrane (SLIM) criteria. These were selected from 7983 revision THA cases performed during the study period After exclusion criteria were applied, 42 cases (59.5% women) with an average age of 63.6 years were included. The mean duration of follow up was 70 months (range 30-122 months). Of these, 73.8% underwent index surgery after primary THA implantation. The primary indication for revision surgery was predominantly the clinical suspicion of arthrofibrosis (n = 35). The Harris Hip Score (HHS) and the EQ-5D-3 L scores were calculated for all cases at the time of follow-up. For the risk analysis of a poor clinical outcome, two groups were divided according to the Harris Hip Score. The group with a poor clinical outcome was defined as a HHS < 55.

RESULTS: Open arthrolysis was performed in all cases with a modular component being replaced in 73.8% of cases (n = 31) and only two cases requiring additional revision of the femoral and acetabular components due to aseptic loosening.The mean pre op Harris Hip Score (HHS) was 53.2 before revision surgery. This increased to 65.7 post op (p < 0.001). Only 34.1% of patients achieved the minimum clinical significance difference (MCID) of 18 HHS points after surgical revision. The EQ-5D Visual Analogue Scale (VAS) score and the Time Trade-Off (TTO) score averaged 0.226 (SD 0.245) and 0.221 (SD 0.37). Complications occurred in seven cases (16.7%,), with dislocation in 2 cases and persistent AF symptoms in 3 cases. Six cases required further revision surgery (14.3%). In three cases, a further open arthrolysis was performed due to persistent symptoms. Increased BMI (30.1 vs. 26.7 BMI, p < 0.05) or higher body weight (88.4 kg vs. 78.7 kg, p = 0.086), smoking and a lower preoperative HHS (p = 0.022) were identified as risk factors for a poor clinical outcome, defined as HHS < 55.

CONCLUSION: Results of this study suggest that mid-term clinical results following surgical intervention for arthrofibrosis following THA show a moderate to poor postoperative outcome with an acceptable complication rate. Risk factors for a poor outcome such as increased weight, BMI or smoking should be considered and critically assessed preoperatively.

PMID:40257586 | DOI:10.1007/s00264-025-06533-0

Injury. 2025 Apr 8;56(6):112328. doi: 10.1016/j.injury.2025.112328. Online ahead of print.

ABSTRACT

INTRODUCTION: Bone fractures are recognized as the second most prevalent cause of pain for patients seeking treatment in medical facilities. This study aims to evaluate the efficacy of intranasal and intravenous ketamine in comparison to intravenous morphine in alleviating severe pain in patients presenting to emergency departments with various bone fractures.

METHOD & MATERIAL: The clinical trial was conducted on patients over the age of 18 who presented at the emergency department of Imam Reza Educational and Medical Center with bone fractures. These patients were divided into three groups for treatment: intranasal ketamine at a dose of 1 mg/kg body weight, intravenous ketamine at a dose of 0.5 mg/kg body weight, and intravenous morphine at a dose of 0.1 mg/kg body weight. The severity of pain experienced by patients was documented using the numerical pain rating scale at the time of admission, and then at 15 min, 30 min, and 60 min after drug administration.

RESULTS: The results of the study revealed that there was no statistically significant difference in the efficacy of pain relief among the three study groups (p=0.77). The interaction of (time*type of drug) had no significant effect on pain intensity (p=0.58). There was no statistically significant difference in side effects reported by patients between the three study groups, with the intranasal ketamine group reporting only minor side effects.

CONCLUSION: The results of this study showed significant effects of intranasal ketamine and intravenous ketamine in reducing pain in patients with bone fractures. The findings further suggest that the analgesic effect of intranasal ketamine is comparable to that of intravenous ketamine and morphine, with no significant adverse effects observed.

PMID:40253928 | DOI:10.1016/j.injury.2025.112328