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Efficacy of intranasal ketamine in controlling pain caused by bone fractures: A single-center double blind randomized controlled trial

Injury -

Injury. 2025 Apr 8;56(6):112328. doi: 10.1016/j.injury.2025.112328. Online ahead of print.

ABSTRACT

INTRODUCTION: Bone fractures are recognized as the second most prevalent cause of pain for patients seeking treatment in medical facilities. This study aims to evaluate the efficacy of intranasal and intravenous ketamine in comparison to intravenous morphine in alleviating severe pain in patients presenting to emergency departments with various bone fractures.

METHOD & MATERIAL: The clinical trial was conducted on patients over the age of 18 who presented at the emergency department of Imam Reza Educational and Medical Center with bone fractures. These patients were divided into three groups for treatment: intranasal ketamine at a dose of 1 mg/kg body weight, intravenous ketamine at a dose of 0.5 mg/kg body weight, and intravenous morphine at a dose of 0.1 mg/kg body weight. The severity of pain experienced by patients was documented using the numerical pain rating scale at the time of admission, and then at 15 min, 30 min, and 60 min after drug administration.

RESULTS: The results of the study revealed that there was no statistically significant difference in the efficacy of pain relief among the three study groups (p=0.77). The interaction of (time*type of drug) had no significant effect on pain intensity (p=0.58). There was no statistically significant difference in side effects reported by patients between the three study groups, with the intranasal ketamine group reporting only minor side effects.

CONCLUSION: The results of this study showed significant effects of intranasal ketamine and intravenous ketamine in reducing pain in patients with bone fractures. The findings further suggest that the analgesic effect of intranasal ketamine is comparable to that of intravenous ketamine and morphine, with no significant adverse effects observed.

PMID:40253928 | DOI:10.1016/j.injury.2025.112328

Employment outcomes following thoracic and lumbar fractures in wales: Long term follow up greater than 5 years

Injury -

Injury. 2025 Apr 9;56(6):112326. doi: 10.1016/j.injury.2025.112326. Online ahead of print.

ABSTRACT

STUDY DESIGN: Retrospective study.

OBJECTIVES: To identify outcomes, in particular employment, >5 years following traumatic thoracic and/or lumbar fracture/s.

METHODS: 235 patients between the ages of 18 and 65 were identified from hospital radiology databases having sustained a traumatic thoracic and/or lumbar fracture on CT and/or MRI between 01/01/2013 and 31/12/2017. Questionnaires were sent via post and available emails, with a reminder letter and phone calls. Retrospective data was gathered about employment status pre-fracture and > 5 years post-injury.

RESULTS: 26 (11 %) patients died before follow-up, leaving 209 patients. 108 (52 %) were treated surgically and 101 (48 %) conservatively. 106 replies were received, with 85 (80 %) opting in and 21 (20 %) out. 68 (80 %) patients completed full questionnaires, and 17 (20 %) filled out a shortened questionnaire via phone conversation. Of the 85 enrolled patients, 52 (61 %) had undergone surgery, and 33 (39 %) had been treated conservatively. The mean follow-up time was 7.9 years (range 5-11 years). Prior to injury, 66 patients (78 %) were employed and 19 (22 %) unemployed (6 were full-time students, 8 retired). 49 (74 %) previously employed patients had returned to work at follow-up, with 35 (53 %) working the same or increased hours. Regarding employment, there was no significant difference between the treatment groups (p = 0.355) or the fracture classification (p = 0.303). 16 (19 %) patients reported back pain before their injury, whilst 69 (81 %) did not. There were 58 (68 %) cases of new pain, with the most affected area being the lumbar region in 43 (51 %) patients. 32 (38 %) patients reported neurological deficit post-injury: 19 with subjective symptoms, 9 objective symptoms and 4 suffered paralysis.

CONCLUSION: After 5 years or more following a traumatic thoracic and/or lumbar fracture, most individuals return to employment. There was no significant difference between the severity of the fracture or treatment on their employment outcomes.

PMID:40253927 | DOI:10.1016/j.injury.2025.112326

Therapeutic Effects of Bovine Colostrum on Bone Healing, Rehabilitation, and Postoperative Complications: A Prospective, Randomized, Double-Blinded Comparative Trial

JBJS -

J Bone Joint Surg Am. 2025 Apr 18. doi: 10.2106/JBJS.24.00542. Online ahead of print.

ABSTRACT

BACKGROUND: Accelerated recovery from bone injuries is a paramount health-care goal with substantial impacts on physical status and overall well-being. The aim of this study was to evaluate the impact of colostrum supplementation on bone healing in patients with a traumatic extracapsular hip fracture (ECF).

METHODS: Patients with an ECF undergoing internal fixation were randomly assigned to receive either bovine colostrum or whey protein. Bone healing was assessed using the Radiographic Union Score for Hip (RUSH). Physical rehabilitation was evaluated using the Harris hip score (HHS) and the Short Musculoskeletal Functional Assessment (SMFA) within 3 months postoperatively. A generalized estimating equation (GEE) was used to assess the time-by-group interactions of these longitudinal variables. Patients were monitored for postoperative complications for 12 months, with the risk difference (RD) and risk ratio (RR) calculated.

RESULTS: A total of 116 patients with an ECF were included in the final analysis (colostrum group, n = 59; whey group, n = 57). Baseline characteristics, including age, gender, ethnicity, and body mass index, were similar between the groups (p > 0.05 for all). The colostrum group had a significantly greater increase in the RUSH score (β = 0.88; p = 0.001) and HHS (β = 1.2; p = 0.001) over time compared with the whey group. SMFA dysfunction and bother indices demonstrated significantly greater decreases over time in the colostrum group compared with the whey group (β = -1.2 and -2.4, respectively; p < 0.001 for both).

CONCLUSIONS: The present study provides preliminary evidence suggesting that colostrum may accelerate bone healing and enhance short-term physical rehabilitation outcomes more effectively than whey protein.

LEVEL OF EVIDENCE: Therapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.

PMID:40249794 | DOI:10.2106/JBJS.24.00542

Retrograde femoral nailing for deformity correction and fracture treatment in osteogenesis imperfecta: clinical and radiological assessment of a novel technique

SICOT-J -

SICOT J. 2025;11:26. doi: 10.1051/sicotj/2025020. Epub 2025 Apr 17.

ABSTRACT

INTRODUCTION: Intramedullary anterograde femoral nailing is a standard treatment for femoral deformity and fracture in osteogenesis imperfecta (OI). This study evaluates the clinical and radiological outcomes of a novel retrograde femoral nailing technique.

METHODS: A retrospective analysis was performed on 31 patients with OI who underwent retrograde femoral nailing using Dubow-Bailey nails from 2004 to 2019. A total of 54 femurs were treated for femoral deformity or fracture by three senior surgeons, with a mean follow-up of 2.7 years. Clinical outcomes, including knee range of motion and pain, were assessed. Radiological outcomes included deformity angle (DA), neck shaft angle (NSA), mechanical lateral distal femoral angle (mLDFA), and nail positioning on AP and lateral X-rays. Potential complications, including hip osteonecrosis, distal femoral growth arrest, and infections, were also evaluated.

RESULTS: The procedure showed favorable outcomes, with no postoperative knee motion limitations or persistent pain. The mean pre-operative DA on AP and lateral views was 29° and 40°, respectively, with no residual deformity after surgery. The mean NSA and mLDFA were 132° and 101° before surgery, compared to 143° and 89° post-operatively. Nail alignment was optimal in 81% of the femurs, with proper positioning in both the distal epiphysis and femoral neck. No cases of hip osteonecrosis, distal femoral growth arrest, or infection were reported. Hardware migration occurred in seven cases.

CONCLUSION: Retrograde femoral nailing is a safe and effective technique for managing femoral deformities and fractures in OI.

PMID:40245284 | PMC:PMC12005622 | DOI:10.1051/sicotj/2025020

Comparing different minimally invasive screw osteosyntheses methods for the stabilization of the sacral fractures

Injury -

Injury. 2025 Apr 8;56(6):112317. doi: 10.1016/j.injury.2025.112317. Online ahead of print.

ABSTRACT

BACKGROUND CONTEXT: Percutaneous screw osteosynthesis is the gold standard for managing sacral fragility fractures in geriatric patients with immobilizing pain. However, comparative evidence regarding the optimal type, length, or insertion position of sacroiliac screws remains limited.

PURPOSE: This study aimed to compare outcomes between long transsacral screws bridging both sacroiliac joints and short sacroiliac screws.

STUDY DESIGN/SETTING: Retrospective cohort single-center study.

PATIENT SAMPLE: Geriatric patients treated with percutaneous sacroiliac screws for sacral fragility fractures.

OUTCOME MEASURES: Primary outcome: screw loosening at 3-, 6-, and 12-month follow-ups.

SECONDARY OUTCOMES: surgical duration, postoperative pain, mobility improvement, and hospital stay length.

METHODS: Data from 122 patients (median age 81, 84 % female) treated between 2018 and 2021 were analyzed. Patients were categorized into three groups [1]: two long transsacral screws [2], a combination of one long and two short screws, and[3] four short sacroiliac screws. Fracture characteristics, FFP classification, and risk factors for screw loosening were evaluated.

RESULTS: Fractures were bilateral in 73 %, with FFP classifications of type 2 (48 %), type 3 (12 %), and type 4 (40 %). Anterior pelvic fractures were present in 63 %, comminuted fractures in 34 %, and H-type fractures in 29 %. Loosening rates were 17 % in the long-screw group, 6 % in the combination group, and 4 % in the short-screw group. Surgical duration was shortest for long screws (mean 52.6 min) compared to the combination (61.8 min) and short-screw (83.4 min) groups. Pain scores decreased below 5 in 88 % of patients at 3 months and 92 % at 12 months. Screw length was a significant risk factor for loosening (p = 0.04).

CONCLUSIONS: Long transsacral screws offer minimally invasive fixation with reduced surgical duration but higher loosening rates. Osteosynthesis with four short sacroiliac screws demonstrates superior long-term stability, making it a promising option for sacral fragility fractures.

PMID:40245455 | DOI:10.1016/j.injury.2025.112317

Risk of Venous Thromboembolism in Pediatric Patients with Surgically Treated Lower-Extremity Fractures: A Propensity-Matched Cohort Study

JBJS -

J Bone Joint Surg Am. 2025 Apr 17. doi: 10.2106/JBJS.24.00810. Online ahead of print.

ABSTRACT

BACKGROUND: Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a substantial cause of morbidity and mortality among hospitalized patients. Although rare in the general pediatric population, VTE remains a potential concern in hospitalized children, particularly those with lower-extremity (LE) fractures. With this study, we aimed to determine the risk of VTE in pediatric patients with surgically treated LE fractures through a retrospective, propensity-matched, cohort analysis.

METHODS: The TriNetX Research Network, encompassing data from >80 health-care organizations and >120 million patient records, was utilized for this retrospective cohort study comparing 3 age-based cohorts (children [age of <14 years], adolescents [age of 14 to 17 years], and adults [age of ≥18 years]) who underwent surgical treatment of LE fractures between January 1, 2003, and January 1, 2023.

RESULTS: A total of 634,880 patients with surgically treated LE fractures were included; 13.3% were children, 5.6% were adolescents, and 81.1% were adults. Propensity-score matching was used to compare VTE incidence across cohorts, resulting in 3 independent matched comparisons. Overall, the incidence of VTE (either DVT or PE) was 0.2% in children, 1.0% in adolescents, and 4.1% in adults. Adults had a significantly higher risk of developing DVT (risk ratio [RR]: 17.0; 95% confidence interval [CI]: 14.5 to 20.0) and PE (RR: 21.8; 95% CI: 17.0 to 28.1) compared with children. Similarly, adolescents had a higher risk of DVT (RR: 3.5; 95% CI: 2.7 to 4.4) and PE (RR: 3.1; 95% CI: 2.2 to 4.4) compared with children. The incidence of VTE varied by fracture location, with femoral and knee joint (incidence: 0.5% in children, 2.5% in adolescents) and pelvic and hip joint (incidence: 1.2% in children, 2.8% in adolescents) fractures presenting the highest risk across all age groups.

CONCLUSIONS: The incidence of VTE in a large cohort of pediatric patients undergoing surgical treatment of LE fractures was higher in adolescents than in children. These findings may warrant prophylactic VTE measures in adolescents undergoing surgical treatment of femoral or pelvic fractures.

LEVEL OF EVIDENCE: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.

PMID:40245162 | DOI:10.2106/JBJS.24.00810

Assessing the Need for Additional Syndesmotic Stabilization in Open Reduction of the Posterior Malleolus: A Biomechanical Study

JBJS -

J Bone Joint Surg Am. 2025 Apr 17. doi: 10.2106/JBJS.23.01088. Online ahead of print.

ABSTRACT

BACKGROUND: The treatment of ankle fractures involving the posterior malleolus (PM) has changed in favor of open reduction and internal fixation (ORIF), and the need for additional syndesmotic stabilization has decreased; however, there are still doubts regarding the diagnosis and treatment of residual syndesmotic instability. The aim of the present study was to evaluate the effect of fixation of the PM and to assess the need for additional stabilization methods. We hypothesized that ORIF of the PM would not sufficiently stabilize the syndesmosis and that additional syndesmotic reconstruction would restore kinematics.

METHODS: Eight unpaired, fresh-frozen, cadaveric lower legs were tested in a 6-degrees-of-freedom robotic arm with constant loading (200 N) in the neutral position and at 10° dorsiflexion, 15° plantar flexion, and 30° plantar flexion. The specimens were evaluated in the following order: intact state; osteotomy of the PM; transection of the anterior inferior tibiofibular ligament (AITFL) and interosseous ligament (IOL); ORIF of the PM; additional syndesmotic screw; combination of syndesmotic screw and AITFL augmentation; and AITFL augmentation.

RESULTS: A complete simulated rupture of the syndesmosis (PM osteotomy with AITFL and IOL transection) caused translational (6.9 mm posterior and 1.8 mm medial displacement) and rotational instability (5.5° external rotation) of the distal fibula. ORIF of the PM could eliminate this instability in the neutral ankle position, whereas sagittal and rotational instability remained in dorsiflexion and plantar flexion. The remaining instability could be eliminated with an additional procedure, without notable differences between screw and AITFL augmentation.

CONCLUSIONS: In our model, isolated PM osteotomy and isolated AITFL and IOL rupture (after PM refixation) only partially increased fibular motion in dorsiflexion and plantar flexion, whereas the combination of PM osteotomy and AITFL and IOL rupture resulted in an unstable syndesmosis in all planes.

CLINICAL RELEVANCE: In complex ankle fractures, ORIF of the PM is essential to restore syndesmotic stability; however, residual syndesmotic instability can be detected by a specific posterior shift of the fibula on stress testing. In these cases, anatomical AITFL augmentation is biomechanically equivalent to the use of a syndesmotic screw.

PMID:40245116 | DOI:10.2106/JBJS.23.01088

AOA Critical Issues Symposium: Current Opinion in Orthopaedics: Orthopaedic Physician Leadership in the Evolving Academic Health-Care System

JBJS -

J Bone Joint Surg Am. 2025 Apr 17. doi: 10.2106/JBJS.24.01493. Online ahead of print.

ABSTRACT

Orthopaedic surgeons are called upon to lead in numerous clinical settings, but the importance of physician leadership is also relevant to administrative roles. As the complexity of health care has increased, the challenges confronting the orthopaedic physician leader have increased as well. During the past century, there has been a substantial increase in the number of non-physician CEO leaders, and this is particularly critical in the academic health system, for which investment in the research and education missions is heavily dependent upon the clinical enterprise. Therefore, physician leadership becomes even more important, with heightened influence. Being an orthopaedic surgeon, or any type of physician, is not synonymous with excellence in leadership. Rather, growth as a leader requires hard work dedicated to the acquisition and nurturing of the knowledge, behaviors, and competencies that result in excellence. We readily acknowledge that physicians must work with a multidisciplinary administrative team of content experts but believe that true expert leaders also possess the inherent knowledge and expertise in the core business for which the organization exists. We encourage our physician colleagues to work to become stronger leaders regardless of their ultimate career aspirations.

PMID:40245106 | DOI:10.2106/JBJS.24.01493

Ultrasound-guided percutaneous cryoneurolysis of intercostal nerves in traumatic rib fractures

Injury -

Injury. 2025 Apr 9:112321. doi: 10.1016/j.injury.2025.112321. Online ahead of print.

ABSTRACT

BACKGROUND: Multimodal pain control is the cornerstone of managing acute traumatic rib fractures. We employed surgeon-administered, ultrasound-guided percutaneous cryoneurolysis of intercostal nerves (USPCNIN) as an adjunct opioid-sparing analgesic modality at the bedside.

METHODS: This was a single-institution case series. Patients between 18-64 years of age who sustained traumatic rib fracture between ribs 3-9, deemed ineligible for surgical stabilization, and had pre-procedure numeric pain scores ≥5 underwent USPCNIN within 24 h of study enrollment by an attending chest wall surgeon. Primary outcomes were changes in daily narcotic use and numeric pain score from pre-intervention up to 30-day follow-up visits. Additional outcomes included hospital length of stay, procedure-related adverse events, and rib-specific readmission.

RESULTS: Fifteen patients were identified. Median (IQR) patient age was 52 (43, 58) years and four (27 %) were female. Median (IQR) number of rib fractures was 5 (4, 8). Median (IQR) hospital length of stay was 4 (3, 7) days. Daily opioid use (measured in morphine milligram equivalents, MME) and present pain intensity (PPI) decreased significantly from pre-intervention to hospital discharge (median MME 96.5 vs. 49.5, p = 0.043; median PPI 10 vs. 7, p = 0.020). Twelve patients completed 30-day follow-up and had significantly decreased MME and PPI from hospital discharge (median MME 62.3 vs. 5, p = 0.014; median PPI 6.5 vs. 3, p = 0.001). There were no complications directly attributable to the procedure. There were no rib-specific readmissions.

CONCLUSION: USPCNIN is a minimally-invasive, bedside procedure that can be safely performed by trauma surgeons and augment pain control for acute traumatic rib fractures.

PMID:40240230 | DOI:10.1016/j.injury.2025.112321

Early clinical outcomes of Naton robotic-assisted medial unicompartmental knee arthroplasty

International Orthopaedics -

Int Orthop. 2025 Apr 16. doi: 10.1007/s00264-025-06519-y. Online ahead of print.

ABSTRACT

PURPOSE: Unicompartmental Knee Arthroplasty (UKA) has garnered increasing attention in recent years. Robotic-assisted systems have demonstrated enhanced precision, contributing to improved patient survival rates, satisfaction, soft-tissue balancing, alignment, and component sizing. The purpose of this study is to evaluate the early clinical outcomes of Naton robotic-assisted medial UKA by analyzing postoperative radiographic positioning of the unicompartmental prosthesis and comparing preoperative and postoperative functional outcomes in patients.

METHODS: A retrospective analysis was conducted on the clinical data of 32 patients (32 knees) who underwent Naton robotic-assisted medial UKA at Suining Central Hospital of Sichuan Province from November 2023 to January 2024. The cohort included ten males and 22 females, with a mean age of 70.53 ± 8.08 years, ranging from 53 to 88 years. All patients underwent surgery using the Naton robotic system and the Zhengtian Unique fixed-bearing UKA prosthesis. Radiographic (X-ray) findings, knee function, and complications were evaluated during follow-up. Radiographic assessments included prosthesis position, angle deviation, and posterior tibial slope (PTS). Knee function was assessed using a range of motion (ROM), Knee Society Score (KSS), Oxford Knee Score (OKS), and Forgotten Joint Score (FJS).

RESULTS: All patients in the study were followed for a period of eight to ten months, with a mean follow-up of (9.16 ± 0.68) months. No complications such as poor incision healing, periprosthetic infection, periprosthetic fracture, or prosthesis loosening were observed during the follow-up period. The medial unicondylar prostheses were found to be in place in all 32 cases, and no abnormal deviation of the prosthesis implantation angle was observed compared to immediate postoperative radiographs. The posterior tibial slope (PTS) was reduced from 13.00 ± 2.72° preoperatively to 5.08 ± 1.14° postoperatively, with a statistically significant difference (P ≤ 0.05). At the final follow-up, the knee range of motion (ROM) was improved from 107.03 ± 11.69° preoperatively to 128.25 ± 16.52° postoperatively. The KSS was improved from 46.28 ± 7.27 to 82.34 ± 14.72, and the OKS was improved from 36.13 ± 4.71 to 15.78 ± 3.52, all with statistically significant differences compared to preoperative values (P ≤ 0.05). The Forgotten Joint Score (FJS) was recorded as 89.2 ± 2.9.

CONCLUSIONS: The short-term follow-up indicates a favorable prosthesis in situ rate for unicompartmental knee arthroplasty assisted by the Naton robot, with satisfactory knee function and patient-reported outcomes. The short-term clinical outcomes are satisfactory.

PMID:40237792 | DOI:10.1007/s00264-025-06519-y

Safety and outcomes of bikini-incision DAA for hip arthroplasty with large acetabular cups (≥56 mm): A single-surgeon series of 215 cases

SICOT-J -

SICOT J. 2025;11:25. doi: 10.1051/sicotj/2025021. Epub 2025 Apr 14.

ABSTRACT

INTRODUCTION: This study evaluates complications associated with the bikini-incision direct anterior approach (DAA) total hip arthroplasty (THA) performed by a single surgeon on a standard operating table, with a focus on cases requiring large acetabular cups (≥56 mm). Secondary objectives include assessing clinical outcomes and implant survivorship.

METHODS: A retrospective analysis was conducted on primary bikini-incision DAA THAs performed by a single surgeon between 2013 and 2024. Cases involving acetabular cups ≥56 mm were included, while emergency hip fracture cases and those requiring posterolateral approaches were excluded. Clinical data, radiographs, and Kaplan-Meier survival analysis were used to assess complications, Harris Hip Scores (HHS), and implant survivorship.

RESULTS: This study included 215 THA procedures performed on 210 male patients (mean age 67 years, BMI 28.6), with an average follow-up of 3.9 years. The primary indication was osteoarthritis (88.4%). The mean preoperative HHS was 41.8, which significantly improved to 92.6 postoperatively (p < 0.001). Complications included lateral femoral cutaneous nerve (LFCN) neuropraxia (2.3%), periprosthetic fractures (0.93%), and femoral stem subsidence (0.93%). The revision rate was 0.93%, with Kaplan-Meier analysis indicating a 99% survival rate for the stem and 100% survival for the acetabular cup at the final follow-up.

DISCUSSION: The bikini-incision DAA THA using a standard operating table provides excellent short- to mid-term functional outcomes and implant survivorship for patients requiring large acetabular cups (≥56 mm). The approach is associated with low complication and revision rates, supporting its safety and efficacy in this cohort.

PMID:40233248 | PMC:PMC11999402 | DOI:10.1051/sicotj/2025021

Prehospital emergency finger thoracostomy in compensated obstructive shock: Benefits and outcomes

Injury -

Injury. 2025 Apr 7:112331. doi: 10.1016/j.injury.2025.112331. Online ahead of print.

ABSTRACT

BACKGROUND: Emergency finger thoracostomy (EFT) has been implemented in several European prehospital settings for intubated and ventilated patients with chest injuries. The indication for intervention in cardiac arrest and peri‑arrest situations is clear. EFT may also be applicable in ventilated but macrohemodynamically compensated patients. This study aims to help prehospital providers understand the benefits and applicability of EFT.

PATIENTS AND METHODS: A retrospective analysis was conducted consisting of 114 EFT cases over 53 months. All chest-injured patients had suspected intrapleural pathology and potential compensated obstructive shock state. Two groups were compared: I. Positive clinical finding after EFT: audible air (pneumothorax (PTX)) and/or blood (hemothorax (HTX)) (n = 85); II. Negative clinical finding: no audible air and/or blood escaping during the procedure (n = 29). The primary endpoint was the effect of EFT on the physiologic parameters. The secondary endpoint was the association between intrathoracic pathology observed during EFT and the physiologic effect.

RESULTS: In 75 % of all cases, after EFT, intrapleural pathology was detectable by on-site physical examination. After EFT SpO2 levels increased from 89.6 % (SD 10.7) to 94.9 % (SD 6.7) (p < 0.001). The other physiological parameters did not change significantly (p = 0.346 or higher). In subgroup analysis, there were appreciable increases in SpO2 for those with PTX or PTX with HTX, that were not seen in those with HTX alone or those with negative clinical findings (p < 0.001). No significant adverse effects of EFT were noted during the prehospital phase or in the hospital follow-up period.

DISCUSSION: EFT performed in ventilated patients with suspected compensated obstructive shock (and stable macrohemodynamic) resulted in audible air and/or blood escape and an improvement in oxygenation if PTX or PTX with HTX were the underlying pathology.

CONCLUSION: Performing an EFT should be considered not only for deteriorating obstructive shock state but also for potentially compensated shock. Even with diagnostic uncertainty, the benefits of an EFT may outweigh the risks.

PMID:40234110 | DOI:10.1016/j.injury.2025.112331

Safety and early outcomes of simultaneous bilateral TKA in patients with BMI &gt; 40: A retrospective comparative study

SICOT-J -

SICOT J. 2025;11:24. doi: 10.1051/sicotj/2025019. Epub 2025 Apr 14.

ABSTRACT

INTRODUCTION: Simultaneous bilateral total knee arthroplasties (SBTKA) are common in Asia, but surgeons may have a body mass index (BMI) threshold for performing these procedures. However, no guidelines regarding patient weight and SBTKA exist in the literature. We hypothesized that SBTKA can be performed safely and efficiently for morbidly obese patients. We aimed to compare 1) the rate of complications within one year after surgery, 2) operative time, blood loss, and length of stay, and 3) clinical outcomes at one year after SBTKA in patients with BMI < 30 versus 30 < BMI < 40 and BMI > 40.

METHODS: In this retrospective comparative matched (age, ASA score) study, we evaluated 113 patients who underwent SBTKA (posterior stabilized cemented TKA), between 2019 and 2022. The patient population was grouped based on their BMI: BMI < 30 (33 patients), 30 < BMI < 40 (43 patients), and BMI > 40 (37 patients). A complication was defined as an event that could be classified as a grade > 3 according to the Clavien-Dindo classification within one year of surgery. Data on complication rate, operation time, blood loss, and preoperative and post-operative function KSS at one year were compared.

RESULTS: No significant difference in the occurrence of early complications between the three groups was observed. One patient was readmitted for periprosthetic fracture in the BMI < 30 group. There was no significant difference in operative time, blood loss, and KSS score at one year between the three groups. A significant functional improvement was observed in all three groups at the one-year follow-up.

DISCUSSION: This study suggests that SBTKA in patients with a BMI > 40 is safe, with no increased complications, similar surgical time, and blood loss. Significant functional improvement was observed at one year postoperatively. While promising, further multi-center studies are needed to confirm these findings and evaluate long-term outcomes.

PMID:40228109 | PMC:PMC11996129 | DOI:10.1051/sicotj/2025019

Changes in bone density, microarchitecture, and biomechanical properties after plate removal in surgically treated distal radius fractures: a prospective study

International Orthopaedics -

Int Orthop. 2025 Apr 14. doi: 10.1007/s00264-025-06529-w. Online ahead of print.

ABSTRACT

PURPOSE: Removal of volar locking plates after healing of a distal radius fracture is becoming increasingly common. However, it is unclear how the fracture healing proceeds and which defects remain. The aim of this study was to assess changes in bone microarchitecture and biomechanical properties in surgically treated radius fracture after volar locking plate removal.

METHODS: Twelve patients were recruited after undergoing plate removal. High Resolution Quantitative Computed Tomography (HR-pQCT) was used to perform scans of the fractured and contralateral distal radius on average one (M1) and 16 months (M2) after plate removal. Parameters measured were cortical- (Dcomp), trabecular- (Dtrab) and total bone density (D100), as well as cortical thickness (Ct.Th). Axial bone stiffness (FE.Kaxial) was determined through linear micro-finite element analysis (µFEA).

RESULTS: At M1, no significant differences between fractured and contralateral side were detected except for Dcomp. At the fractured side, all parameters except for Dtrab increased significantly between M1 and M2. At M2, Ct.Th and FE.Kaxial were significantly higher at the fractured side compared to the contralateral side, but Dcomp remained significantly lower. Qualitatively, closure of the screw holes was observed between M1 and M2, while large trabecular defects remained.

CONCLUSION: Bone (re)modeling at the distal radius is an ongoing process even after plate removal and leads to a partial exaggeration of the bone properties relative to the intact contralateral side. It seems that the bone regains its biomechanical competence by closing screw holes and increasing cortical thickness, which compensates for trabecular defects that cannot be repaired.

LEVEL OF EVIDENCE: III.

PMID:40227373 | DOI:10.1007/s00264-025-06529-w

Arthroscopic cystectomy and open surgery for the treatment of popliteal cysts: a retrospective clinical cohort study

International Orthopaedics -

Int Orthop. 2025 Apr 14. doi: 10.1007/s00264-025-06527-y. Online ahead of print.

ABSTRACT

PURPOSE: To compare the clinical effects of arthroscopic cystectomy and open surgery for the treatment of popliteal cysts, in order to provide clinical basis for the selection of surgical plan for popliteal cyst.

METHODS: A retrospective study was conducted on the clinical data of 153 patients diagnosed with popliteal cysts from January 2020 to December 2022. Among them, 77 patients underwent arthroscopic cystectomy as the observation group, and 76 patients underwent open surgery as the control group. Compared the surgical related indicators, Rauschening and Lindgren grade, Lysholm and VAS scores between two groups. Follow up on postoperative complications and cyst recurrence.

RESULTS: The observation group had a smaller incision length (P < 0.01), less intraoperative bleeding (P < 0.05), and shorter hospitalization time than the control group (P < 0.01), but longer surgical time (P < 0.05). Both groups of patients showed significant improvement in Rauschening and Lindgren grade, Lysholm and VAS scores after surgery, with the observation group superior to the control group(P < 0.05&P < 0.01). Follow up for 13-25 months (16.34 ± 4.25) after surgery showed no complications in the observation group, while there were two cases of nerve injury in the control group, with no statistically significant difference (P > 0.05). There were two cases of postoperative recurrence in the observation group with no symptoms and nine cases of recurrence in the control group with mild symptoms and did not require further treatment, which had statistical difference (P < 0.05).

CONCLUSIONS: Arthroscopic cystectomy and oper surgery both have definite clinical efficacy in treating popliteal cyst, which relying on prospective research to determine the optimal solution.

PMID:40227372 | DOI:10.1007/s00264-025-06527-y

Neck reconstruction in burn sequelae: A comparison of full-thickness skin grafts with traditional tie-over versus negative pressure wound therapy for both recipient site preparation and graft fixation

Injury -

Injury. 2025 Apr 12:112323. doi: 10.1016/j.injury.2025.112323. Online ahead of print.

ABSTRACT

BACKGROUND: Neck reconstruction for burn sequelae can be effectively achieved through release procedures and lower abdomen skin transplantation. This article describes cases in which full-thickness skin grafts (FTSGs) from the lower abdomen were used as donor areas. Although the benefits of negative pressure wound therapy (NPWT) for graft integration are known, its dual use for recipient site preparation and intraoperative graft fixation, specifically in the neck, has been scarcely described. This study evaluates both applications of NPWT-preoperative wound bed optimization and intraoperative graft fixation-highlighting their combined impact on graft take and patient outcomes.

METHODS: Patients treated at a referral burn center between March 2021 and October 2023 with severe neck contractures underwent scar release and FTSG transplantation. Two techniques for graft fixation were compared: the traditional tie-over method and NPWT. Graft integration rates, necrosis percentages, and postoperative complications were assessed.

RESULTS: The study included six patients (tie-over group: 2; NPWT group: 4). The NPWT group demonstrated clinically favorable graft integration rates (92.5 %) and lower necrosis rates (7.5 %) compared with the tie-over group (76.5 % and 23.5 %, respectively). The NPWT technique also resulted in shorter hospital stays and fewer complications.

CONCLUSIONS: The combined use of NPWT for recipient site preparation and intraoperative graft fixation clinically improves graft integration and reduces complications in neck burn reconstruction. These findings suggest that NPWT should be considered a standard of care in settings where resources allow.

PMID:40222842 | DOI:10.1016/j.injury.2025.112323

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