EFORT Open Rev. 2025 Mar 3;10(3):156-165. doi: 10.1530/EOR-24-0087. Print 2025 Mar 1.

ABSTRACT

Neurogenic bladder (NB) is a group of bladder and/or urethral dysfunctions caused by neurological lesions, commonly seen in patients with lumbar spine diseases, manifesting as urinary storage and voiding dysfunction, significantly affecting patients' quality of life. Degenerative changes or trauma to the lumbar spine can lead to narrowing of the dural sac, compressing the sacral nerve roots, cauda equina or blood vessels, causing bladder dysfunction and leading to NB. Diagnostic methods for NB include history taking, physical examination and noninvasive and invasive tests, such as urodynamic testing and cystoscopy. The treatment goals for NB are to protect upper urinary tract function, restore or partially restore lower urinary tract function, improve urinary control, reduce residual urine volume, prevent urinary tract infections and improve patients' quality of life. Treatment methods include conservative treatment, pharmacological treatment, catheterization, neuromodulation and surgical treatment, which should be sequentially administered based on the patient's specific condition.

PMID:40071973 | PMC:PMC11896685 | DOI:10.1530/EOR-24-0087

EFORT Open Rev. 2025 Mar 3;10(3):166-171. doi: 10.1530/EOR-2024-0074. Print 2025 Mar 1.

ABSTRACT

PURPOSE: The pre-operative management of fracture blisters is an area of uncertainty within trauma and orthopaedic surgeries. Management strategies vary significantly between and within orthopaedic departments across the United Kingdom. The purpose of this systematic review was to comprehensively appraise and synthesize the existing literature pertaining to this topic, highlighting current practices and areas for ongoing research.

METHODS: Extensive electronic literature searches were performed on PubMed/MEDLINE (January 1946-May 2024), Embase (January 1974-May 2024) and Cochrane library (January 1933-May 2024) databases. The search terms were as follows: (fracture blister OR bone blister*) AND (dress* OR drain* OR aspirat* OR deroof* OR manage*). These keywords were searched in the subject headings, in title and in abstract.

RESULTS: The results of the search methodology revealed five articles, which represented the best evidence to the clinical question. These papers reported on rates of wound healing and post-operative infection, time to surgical readiness and treatment costs, following varying treatment modalities in 1162 patients. The authors, publication dates, countries, patient groups, study outcomes and results of these papers are tabulated in Supplementary Table 1.

CONCLUSION: Fracture blisters pose a significant challenge in clinical practice, leading to delays in surgery, suboptimal surgical approaches and complications in wound healing post-operatively. Currently, there is no consensus describing the optimal management of these blisters. This review challenges the conventional belief that fracture blisters are sterile, highlighting that the application of topical agents to the deroofed blister bed may expedite surgical readiness.

PMID:40071972 | PMC:PMC11896682 | DOI:10.1530/EOR-2024-0074

EFORT Open Rev. 2025 Feb 3;10(2):115-124. doi: 10.1530/EOR-2023-0121. Print 2025 Feb 1.

ABSTRACT

PURPOSE: To evaluate the clinical and biomechanical evidence for the addition of acromioclavicular (AC) ligament repair and reconstruction in the surgical management of high-grade AC joint (ACJ) dislocation.

METHODS: This is a systematic review of biomechanical and clinical studies that describe AC reconstructive or reparative techniques. The search ranged from 1946 to 2024 and included OVID, MEDLINE, PubMed, CINAHL, Embase, Google Scholar and the Cochrane Library databases. Clinical and biomechanical outcomes were evaluated.

RESULTS: Thirty-two eligible studies were identified. Of these, four biomechanical studies focused on the ACJ exclusively. Twenty-eight other studies (15 clinical and 13 biomechanical) were identified involving reconstruction of the ACJ in addition to the treatment of the coracoclavicular (CC) ligaments. There was clinical evidence of improved outcomes with ACJ repair and reconstruction, although comparison was difficult. In comparative studies, ACJ-specific Taft and acromioclavicular joint instability scores were improved in patients with ACJ reconstruction. Constant score and subjective shoulder value also increased, although this was observed in studies lacking a control group. The biomechanical studies provide evidence of increased translational and rotational stability with ACJ repair and reconstruction, but the optimal technique has not been identified.

CONCLUSION: ACJ repair and reconstruction, in addition to CC repair, results in improved biomechanical and functional outcomes and should be considered when treating high-grade ACJ injuries. There is insufficient evidence in the literature to be able to recommend a specific technique to treat ACJ injuries.

PMID:40071970 | PMC:PMC11825160 | DOI:10.1530/EOR-2023-0121

EFORT Open Rev. 2025 Feb 3;10(2):104-114. doi: 10.1530/EOR-24-0138. Print 2025 Feb 1.

ABSTRACT

PURPOSE: The proximal femur is a frequent site of cancer dissemination in the extremities. Patients treated surgically for skeletal metastases have poorer overall health compared to other orthopedic patients, with only one-third expected to survive two years post-surgery. Choosing a treatment that minimizes revision risk and ensures the implant outlives the patient is therefore crucial. We conducted a systematic review to assess the revision rate following internal fixation (IF) or endoprosthetic reconstruction (EPR) of the proximal femur for metastatic bone disease (MBD).

METHODS: This study adhered to the PRISMA guidelines. MEDLINE and Embase were searched, identifying 10,299 records. After removing duplicates, 7731 unique records were screened, 334 of which were retrieved for full-text screening. We included 34 studies in the qualitative synthesis. The MINORS instrument was used for quality assessment.

RESULTS: The quality of the included studies was low to moderate, with median scores of 6/16 for non-comparative studies and 10/24 for comparative studies. We therefore refrained from a comparative analysis. Revision rates varied between 0 and 12.4% following EPR (25 studies) and between 0 and 26.7% following IF, while implant removal rates ranged between 0 and 8.3% and 0 and 26.7%, respectively.

CONCLUSIONS: Revision and implant removal rates for various methods of EPR and IF are satisfactory. However, a meta-analysis or comparison between IF and EPR is not feasible due to a lack of prospective studies, randomized trials and high-quality studies.

PMID:40071964 | PMC:PMC11825154 | DOI:10.1530/EOR-24-0138

EFORT Open Rev. 2025 Mar 3;10(3):141-150. doi: 10.1530/EOR-2024-0077. Print 2025 Mar 1.

ABSTRACT

PURPOSE: No literature consensus was found about the best treatment of acute Rockwood type III acromioclavicular joint (ACJ) dislocation. In particular, the advantages and disadvantages between conservative treatment and surgery are not sufficiently quantified in the current literature.

METHODS: A systematic literature search was conducted using PubMed, Web of Science and Embase in March 2024. We selected studies comparing surgical and conservative treatment in acute Rockwood III ACJ dislocations. The two treatment methods were compared in terms of Constant score; Disabilities of the Arm, Shoulder, and Hand (DASH); American Shoulder and Elbow Surgeons (ASES) score; Acromioclavicular Joint Instability Score (ACJIS); subjective shoulder value (SSV); radiographical findings; reported complications; and return to sports activity. The risk of bias and quality of evidence were assessed using Cochrane guidelines.

RESULTS: A total of 1844 articles were evaluated, and ten were included in the study for a total of 397 patients. The results of the meta-analysis showed no significant differences between the two groups in terms of Constant score (P = 0.31), DASH (P = 0.52), ASES (P = 0.66) and SSV (P = 0.21), while it highlighted a statistically significant difference in terms of ACJIS (P = 0.00) and acromioclavicular (P = 0.00) and coracoclavicular distance (P = 0.00).

CONCLUSION: The results showed no significant differences in terms of patient-reported or objective functional outcomes between the two treatment groups. Nonetheless, it highlights a difference in terms of radiographical outcomes and type of complications. While surgical intervention is able to improve joint reduction, it adds the risk for surgical complications.

PMID:40071962 | PMC:PMC11896683 | DOI:10.1530/EOR-2024-0077

EFORT Open Rev. 2025 Feb 3;10(2):75-81. doi: 10.1530/EOR-2023-0112. Print 2025 Feb 1.

ABSTRACT

Alkaptonuria is an extremely rare disorder of tyrosine metabolism caused by an autosomal recessive enzymatic deficiency of homogentisic acid (HGA) oxidase, causing its accumulation in collagenous structures, especially in hyaline cartilage. It is characterized by a triad of homogentisic aciduria, bluish-black discoloration of connective tissues (ochronosis) and arthropathy of the spine and large weight-bearing joints. Several clinical manifestations were described including coronary and valvular calcification, aortic stenosis, limited chest expansion, and renal, urethral and prostate calculi as well as ocular and cutaneous pigmentation. Skeletal affection usually presents as spondylotic changes of the spine. The knee is the most common peripheral joint to be involved. Enthesopathy or tendon ruptures may occur, and reduced bone density is not unusual. A low-protein diet and ascorbic acid may reduce HGA levels. Nitisinone can safely and effectively reduce HGA production and urinary excretion. In severe ochronotic arthropathy, joint arthroplasty can offer reliable pain relief and excellent functional outcomes. Cementless fixation is successful in young patients.

PMID:40071956 | PMC:PMC11825137 | DOI:10.1530/EOR-2023-0112

EFORT Open Rev. 2025 Jan 3;10(1):1-2. doi: 10.1530/EOR-2024-0200. Print 2025 Jan 1.

NO ABSTRACT

PMID:40071949 | PMC:PMC11728856 | DOI:10.1530/EOR-2024-0200

EFORT Open Rev. 2025 Jan 3;10(1):48-56. doi: 10.1530/EOR-24-0048. Print 2025 Jan 1.

ABSTRACT

PURPOSE: Pediatric osteoarticular infections (OAIs) are an orthopedic emergency that can lead to severe sequelae if not treated appropriately. Approximately half of the patients with OAIs in clinical practice fail to obtain microbiological results even after undergoing aspiration or surgery, which presents a significant challenge in clinical practice. The inability to identify pathogens can lead to incorrect antibiotic usage or under-treatment, increasing the risk of adverse outcomes. This study aims to investigate the clinical characteristics and prognosis of culture-negative OAIs compared to culture-positive OAIs through a meta-analysis, providing insights to optimize treatment strategies.

METHODS: A systematic search was conducted to identify cohort studies comparing the clinical characteristics and prognosis of children with culture-negative OAIs to those with culture-positive OAIs. The search encompassed the databases of Wanfang Data, China National Knowledge Infrastructure, China Biology Medicine disc, Excerpta Medica Database, PubMed and the Cochrane Library, with the literature review extending up to March 2024. Data were extracted from eligible articles and assessed using the Newcastle-Ottawa scale, and the articles were selected based on predefined inclusion and exclusion criteria.

RESULTS: Twelve literature reports covering 1630 patients were included in this meta-analysis. Publication bias did not significantly affect the results. The incidence of long-term sequelae, temperature before admission, baseline laboratory indicators and possibility of surgery in the culture-negative group of patients were significantly lower than those in the culture-positive group. In addition, there were no significant differences in gender, age, race, trauma history, patient delay, antibiotic usage before admission or clinical symptoms between the two groups.

CONCLUSIONS: Children diagnosed with culture-negative OAIs generally demonstrated less severe systemic inflammatory responses, required shorter treatment durations, exhibited a reduced likelihood of requiring surgical intervention and were less prone to experience long-term functional impairments compared to children with culture-positive OAIs. However, no differences in patient characteristics and clinical symptoms were found between the two groups. Further large-scale studies are still required to validate these findings.

TYPE OF STUDY: Meta-analysis.

LEVEL OF EVIDENCE: Level III.

PMID:40071945 | PMC:PMC11728918 | DOI:10.1530/EOR-24-0048

EFORT Open Rev. 2025 Jan 3;10(1):14-27. doi: 10.1530/EOR-2024-0036. Print 2025 Jan 1.

ABSTRACT

PURPOSE: Investigate intra- and post-operative complications and revisions following distal femoral and/or high tibial derotational osteotomies to correct rotational malalignments of the lower limb in patients with anterior knee pain (AKP) and/or patellofemoral instability (PFI).

METHODS: A literature search was conducted on PubMed, EMBASE and Web of Science (until 30 September 2023), including studies reporting complications, reinterventions and revisions following knee derotational osteotomies. Incidence rates were collected for each level of derotational osteotomy (distal femur, high tibia or double-level). A meta-analysis using the Freeman-Tukey double arcsine transformation was conducted to estimate the pooled proportions with their 95% confidence intervals (CIs).

RESULTS: Twenty-one studies involving 564 osteotomies (n = 484) were included, with a mean follow-up of 45.6 ± 15.7 months. The overall complication proportion was 7.5% (95% CI: 3.9-11.8%). Postoperative residual AKP was seen in a pooled proportion of 7.6% (95% CI: 0.7-18.8%), and persistent PFI was not common (0.1%; 95% CI: 0.0-1.7%). Intraoperative complications occurred in a pooled proportion of 3.8% (95% CI: 2.4-6.0%), with peroneal nerve injury being the most common (1.3%) after derotational high tibial osteotomy. Reintervention was needed in a pooled proportion of 13.0% (95% CI: 2.9-27.2%), primarily for hardware removal (n = 158; 28.3%). There was a pooled proportion of knees requiring revision procedures of 12.3% (95% CI: 2.6-26.1%).

CONCLUSIONS: Distal femur and high tibial derotational osteotomies exhibit a considerable incidence of intra- and post-operative complications. Peroneal nerve injury, although infrequent, is a significant complication, underscoring the importance of implementing intraoperative preventive measures during derotational high tibial osteotomy.

PMID:40071944 | PMC:PMC11728914 | DOI:10.1530/EOR-2024-0036

EFORT Open Rev. 2025 Jan 3;10(1):3-13. doi: 10.1530/EOR-2024-0014. Print 2025 Jan 1.

ABSTRACT

PURPOSE: To compare anesthesia techniques (WALANT (wide-awake anesthesia no tourniquet), locoregional anesthesia, local anesthesia with tourniquet or sedation) for carpal tunnel release (CTR).

METHODS: A comprehensive literature search was conducted on PubMed, MEDLINE, Embase and the Cochrane Library up to May 2023. Two independent reviewers selected the studies and extracted the data. The primary outcomes included the pain experienced at the moment of anesthesia and during the surgery and the mean morphine equivalents (MME) administered following the surgery and overall patient satisfaction. Our secondary outcomes consisted of the mean room occupancy time and the mean duration of the procedure, followed by the complication rate. The review process was conducted according to PRISMA guidelines.

RESULTS: A total of 3166 studies were identified, which included 23 studies comparing various anesthesia types and 28,748 CTR surgeries. The WALANT group experienced significantly lower pain levels during anesthesia (-2.67 (95% CIs: 0.12-4.99)) and surgery (-2.04 (95% CIs: 0.08-4.07)) compared to the local anesthesia group. There was no difference in the use of MME for pain relief among different anesthesia techniques. Satisfaction rates were comparable, but WALANT exhibited the highest probability for utmost satisfaction. The mean room occupancy time was lower in patients receiving local anesthesia compared with when sedation was added, with a mean difference of -27.16 (95% CIs: -52.03 to -1.85).

CONCLUSIONS: The WALANT technique for CTR reported better outcomes for pain (during anesthesia and surgery), higher satisfaction and low probability to expand the operating room occupancy time.

LEVEL OF EVIDENCE: Level II of evidence.

PMID:40071930 | PMC:PMC11728873 | DOI:10.1530/EOR-2024-0014

EFORT Open Rev. 2025 Jan 3;10(1):57-63. doi: 10.1530/EOR-24-0110. Print 2025 Jan 1.

ABSTRACT

Esophageal perforation is a rare but serious complication that can occur post-cervical spine surgery. This case report presents the clinical course, diagnostic challenges and management strategies of a patient who had a late-diagnosis esophageal perforation after anterior cervical spine surgery (ACSS). A woman in her 50s underwent ACSS for cervical spondylosis. Three months postoperatively, she experienced persistent right neck and shoulder pain. Despite multiple consultations, an esophageal perforation was only diagnosed 10 years later when a neck mass ruptured, discharging food debris. Surgical management included removing the anterior cervical plate and reconstruction with a sternocleidomastoid muscle flap. Postoperatively, she faced wound complications, and the perforation failed to heal despite multiple debridement and stent placements. Ultimately, complete excision of the diverticulum, repair of the perforation and muscle flap reconstruction led to her recovery, with no recurrence over an 8-year follow-up. We reviewed the literature on cases with esophageal perforation occurring more than 10 years after anterior cervical surgery and summarized the treatment experiences. This case underscores the diagnostic challenges and delayed presentation of esophageal perforation post-ACSS. Early recognition and multidisciplinary management are essential. In cases of late perforation, hardware removal, diverticulum excision and a muscle flap are critical to achieving successful closure of the esophageal lesion, preventing recurrence and ensuring comprehensive repair. Addressing esophageal diverticula during perforation treatment is crucial to prevent recurrence and ensure thorough repair. This highlights the need for high clinical suspicion and a coordinated surgical approach to improve patient outcomes.

PMID:40071924 | PMC:PMC11728875 | DOI:10.1530/EOR-24-0110

EFORT Open Rev. 2025 Jan 3;10(1):28-36. doi: 10.1530/EOR-2024-0070. Print 2025 Jan 1.

ABSTRACT

PURPOSE: A staged bilateral total knee arthroplasty (BTKA) procedure is considered when a patient is not deemed suitable for simultaneous BTKA due to concerns about the risk of mortality and complications. However, no network meta-analysis has been conducted to compare simultaneous vs staged BTKA procedures with different intervals in terms of postoperative mortality and overall complication rates.

METHODS: Four databases - Medline, Embase, Cochrane Library and Web of Science - were searched from inception to December 19, 2023, for studies comparing patients who underwent staged BTKA with different intervals and simultaneous BTKA. The primary outcome domains were 1-year mortality and 90-day overall complications. Secondary outcomes included neurological, cardiovascular, pulmonary, infectious and venous thromboembolic complications within 90 days.

RESULTS: Fifteen observational studies were included. Staged BTKA with intervals between 6 weeks and 3 months (odds ratio (OR): 0.69, 95% CI: 0.53-0.91), between 3 and 6 months (OR: 0.67, 95% CI: 0.53-0.84) and longer than 6 months (OR: 0.67, 95% CI: 0.55-0.83) exhibited a lower mortality risk compared to simultaneous BTKA. Staged BTKA with an interval shorter than 6 weeks and longer than 6 months exhibited a higher risk of pulmonary (OR: 1.24, 95% CI: 1.03-1.49; OR: 1.64, 95% CI: 1.10-2.44) and infectious complications (OR: 1.50, 95% CI: 1.15-1.96; OR: 1.52, 95% CI: 1.14-2.02) compared to simultaneous BTKA. An interval between 3 and 6 months ranked best in outcomes of 1-year mortality (P score = 0.7849) and 90-day complications (P score = 0.7077).

CONCLUSIONS: Staged BKTA with an interval of more than 6 weeks but less than 6 months is associated with a lower risk of postoperative mortality and complications. However, these results should be interpreted with caution due to potential biases inherent in the inclusion of nonrandomized studies.

LEVEL OF EVIDENCE: II.

PMID:40071914 | PMC:PMC11728876 | DOI:10.1530/EOR-2024-0070

EFORT Open Rev. 2025 Jan 3;10(1):37-47. doi: 10.1530/EOR-2023-0209. Print 2025 Jan 1.

ABSTRACT

Knee osteoarthritis (OA) is a common chronic condition that leads to joint pain and disability among older adults. An interprofessional collaborative approach has nowadays been widely advocated in knee OA management although little is known about the characteristics of care, roles and responsibilities of healthcare providers and how they collaborate as a team to optimise treatment outcomes. The Donabedian structure-process-outcome framework was used in the review. Six databases were searched from February 2013 to March 2023. A total of 26 articles that met our inclusion criteria were reported. All studies (n = 26) identified the physiotherapist as a critical member of the interprofessional team. Several studies (n = 5) have offered training to healthcare providers in the management of knee OA. The intervention components in most studies included disease-based education (n = 21) and exercise therapy (n = 16). A comprehensive understanding of the existing interprofessional knee OA care in this review could potentially assist the government and healthcare organisations in developing interprofessional practice guidelines and designing intervention programmes that maximise their benefits.

PMID:40071912 | PMC:PMC11728870 | DOI:10.1530/EOR-2023-0209

Injury. 2025 Mar 8;56(4):112236. doi: 10.1016/j.injury.2025.112236. Online ahead of print.

ABSTRACT

INTRODUCTION: Serotonergic antidepressants, including both selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have been linked to adverse outcomes following orthopedic procedures. This study aims to evaluate the impact of SSRIs/SNRIs on outcomes in patients following operative fixation of the femur. We hypothesized that perioperative use of SSRIs would be associated with worse outcomes post-surgery.

METHODS: A retrospective cohort analysis was conducted using the TriNetX global federated research network. Adult patients (>18 years) with femur fractures treated surgically were identified using Current Procedural Terminology (CPT) and International Classification of Disease (ICD-10) codes. Propensity score matching was performed to create two cohorts: patients using SSRIs/SNRIs and non-users, each consisting of 5,477 matched patients. Outcomes assessed included postoperative bleeding complications, intensive care unit (ICU) requirement, and wound dehiscence.

RESULTS: On the day of surgery, there were no differences in rates of acute post-hemorrhagic anemia (12 % vs 12 %, p = 0.86), hemoglobin <7g/dL (6 % vs 6 %, p = 0.97) or transfusion (4.9 % vs 4.4 %, p = 0.24). From postoperative day 1-7, rates of acute post-hemorrhagic anemia (18 % vs 16 %, p < 0.01), hemoglobin < 7 g/dL (29 % vs 24 %, p < 0.01) and transfusion (9.5 % vs 8.0 %, p < 0.01) were significantly higher in the SSRI/SNRI cohort. From postoperative day 7-30, there were no observed differences in rates for acute post-hemorrhagic anemia, hemoglobin <7g/dL, transfusion and hematoma incision and drainage.

CONCLUSIONS: Perioperative use of SSRIs/SNRIs in patients with femur fractures is associated with increased risk of acute bleeding complications (Day 1-7); however, the increased risk of bleeding complications is not observed beyond one week postoperatively. Balancing surgical risk with mental health needs is crucial. These findings underscore the importance of careful management of patients with SSRIs/SNRIs undergoing orthopedic procedures, particularly in terms of postoperative blood loss anemia and the need for transfusion.

PMID:40073712 | DOI:10.1016/j.injury.2025.112236

Injury. 2025 Mar 8;56(4):112233. doi: 10.1016/j.injury.2025.112233. Online ahead of print.

ABSTRACT

PURPOSE: The aim of the present study was to explore the impact of different planes of popliteal artery injury (PAI) on the risk of amputation in affected limbs.

METHODS: A retrospective analysis was conducted on ninety-four patients who underwent PAI; these patients were divided into an amputation group (n = 26) and a nonamputation group (n = 68) on the basis of whether limb preservation was successful. The data were reconstructed from computed tomography angiography (CTA) of the patients' lower limbs and measured via AW Volume Share 5 software. The height of the popliteal artery injury surface was quantified as follows: "L" was defined as the distance from the origin of the descending genicular artery of the contralateral limb to the origin of the anterior tibial artery; "S" was defined as the distance from the origin of the descending genicular artery of the affected limb to the blood flow interruption site; and "R" was defined as the ratio of S to L (S/L). The risk factors for amputation in patients with PAI were also analysed.

RESULTS: Univariate and multivariate logistic regression analyses revealed that R (odds ratio [OR]=0.876, P = 0.006,95 % CI:0.797-0.963), S (OR=0.792, P = 0.166,95 % CI:0.570-1.102), ischemic time (OR=1.195, P = 0.017,95 % CI:1.032-1.383), and compartment syndrome (OR=5.509, P = 0.055,95 % CI:0.967-31.376) were independent risk factors for amputation in patients with PAI. The receiver operating characteristic (ROC) curve revealed that the AUC values were 0.887 (P < 0.000, 95 % CI: 0.805-0.943) and 0.775 (P < 0.000, 95 % CI: 0.677-0.854) for R and S, respectively. The diagnostic efficiency was highest when the diagnostic threshold values were 0.573 and 11.3 cm, for R and S, respectively. Moreover, the AUCR was greater than the AUCS (Z = 2.403, P = 0.0162).

CONCLUSION: The height of the PAI plane is an independent risk factor for amputation in patients with PAI. Greater planes of vascular injury result in greater risk of amputation. R is better than S in the diagnosis of amputation risk in patients with PAI.

PMID:40073711 | DOI:10.1016/j.injury.2025.112233

J Bone Joint Surg Am. 2025 Mar 10. doi: 10.2106/JBJS.23.01137. Online ahead of print.

ABSTRACT

BACKGROUND: Identifying patients at high risk for failure of primary anterior cruciate ligament reconstruction (ACLR) on the basis of preoperative magnetic resonance imaging (MRI) measurements has received considerable attention. In this study, we aimed to identify potential risk factors for primary ACLR failure from preoperative MRI measurements and to determine optimal cutoff values for clinical relevance.

METHODS: Retrospective review and follow-up were conducted in this nested case-control study of patients who underwent primary single-bundle ACLR using hamstring tendon autograft at our institution from August 2016 to January 2018. The failed ACLR group included 72 patients with graft failure within 5 years after primary ACLR, while the control group included 144 propensity score-matched patients without failure during the 5-year follow-up period. Preoperative MRI measurements were compared between the 2 groups. Receiver operating characteristic (ROC) curve analyses were conducted to determine the optimal cutoff values for the significant risk factors. Odds ratios (ORs) were calculated, and survival analyses were performed to evaluate the clinical relevance of the determined thresholds.

RESULTS: A greater lateral femoral condyle ratio (LFCR) (p = 0.0076), greater posterior tibial slope in the lateral compartment (LPTS) (p = 0.0002), and greater internal rotational tibial subluxation (IRTS) (p < 0.0001) were identified in the failed ACLR group compared with the control group. ROC analyses showed that the optimal cutoff values for IRTS and LPTS were 5.8 mm (area under the curve [AUC], 0.708; specificity, 89.6%; sensitivity, 41.7%) and 8.5° (AUC, 0.655; specificity, 71.5%; sensitivity, 62.5%), respectively. Patients who met the IRTS (OR, 6.14; hazard ratio [HR], 3.87) or LPTS threshold (OR, 4.19; HR, 3.07) demonstrated a higher risk of primary ACLR failure and were significantly more likely to experience ACLR failure in a shorter time period.

CONCLUSIONS: Preoperative MRI measurements of increased IRTS, LPTS, and LFCR were identified as risk factors for primary ACLR failure. The optimal cutoff value of 5.8 mm for IRTS and 8.5° for LPTS could be valuable in the perioperative management of primary ACLR.

LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

PMID:40063685 | DOI:10.2106/JBJS.23.01137

Int Orthop. 2025 Mar 10. doi: 10.1007/s00264-025-06483-7. Online ahead of print.

NO ABSTRACT

PMID:40063117 | DOI:10.1007/s00264-025-06483-7

Int Orthop. 2025 Mar 10. doi: 10.1007/s00264-025-06479-3. Online ahead of print.

ABSTRACT

PURPOSE: This retrospective cohort study aimed to compare the clinical outcomes of percutaneous transforaminal endoscopic decompression (PTED) with those of posterior lumbar interbody fusion (PLIF) for the treatment of degenerative lumbar scoliosis (DLS) with lumbar spinal stenosis (LSS).

METHODS: In this study, 143 DLS patients who met the inclusion criteria from January 2016 to March 2019 were retrospectively analyzed and divided into the PTED and PLIF groups. The propensity score matching (PSM) method was used to adjust for imbalanced confounding variables between the groups. The visual analog scale (VAS) and Oswestry Disability Index (ODI) scores were then used to compare the clinical outcomes between the two groups. Furthermore, changes in radiological characteristics and surgical complications were assessed.

RESULTS: After PSM, 86 patients were included in the study with a followup duration of at least five years. Postoperative VAS and ODI scores were significantly improved in both groups at all time points compared with preoperative values (p < 0.001). However, the PTED group had higher VAS scores for back pain and ODI scores than the PLIF group at five years postoperatively (p < 0.05). For radiological parameters, the Cobb angle decreased in the PLIF group but increased in the PTED group at the final followup (p < 0.05). A decrease in the adjacent disc height was observed in the PLIF group at the final followup (p < 0.001).

CONCLUSION: Both PTED and PLIF achieved relatively satisfactory outcomes in treating DLS with LSS after a minimum five year followup. However, further studies are required to better determine the characteristics of spinal deformities amenable to each procedure.

PMID:40063116 | DOI:10.1007/s00264-025-06479-3

Injury. 2025 Mar 3:112238. doi: 10.1016/j.injury.2025.112238. Online ahead of print.

ABSTRACT

INTRODUCTION: Enhanced Recovery Protocols (ERPs) are designed to improve postoperative recovery. Since their inception, ERPs have become the standard of care across multiple surgical specialities, with numerous guidelines established for elective procedures. While ERP principles have been extended to emergency abdominal surgeries, their application in trauma laparotomy remains limited. This study details the development of an ERP tailored for trauma laparotomy patients and evaluates outcomes following its implementation.

METHODS: A multidisciplinary team developed an ERP, termed the Trauma Laparotomy Care Pathway (TLCP), grounded in best available evidence and adapted to our clinical setting through a rigorous consensus process. Following implementation, we conducted a single-center pilot study as part of a quality improvement initiative, comparing trauma laparotomy patients managed with TLCP from February to July 2024 to a historical cohort as the baseline group. We analyzed adherence to five key postoperative components and assessed impacts on postoperative outcomes.

RESULTS: In the first six months post-implementation, 31 patients were managed using TLCP. The median age was 32.0 years, with males comprising 87.1 % of patients. Stab wounds were the most frequent injury mechanism, followed by motor vehicle-related accidents and falls. Isolated abdominal injuries accounted for 64.5 % of cases. Adherence to key pathway components ranged from 54.5 % to 67.7 %. The hospital length of stay was significantly shorter for the TLCP group, showing a two-day reduction compared to the historical cohort (4.0 days [3.5, 6.5] vs 6.0 days [4.0, 10.0], p = 0.002). There was no significant difference in in-hospital complications or 30-day readmission rates between the groups.

CONCLUSION: Following TLCP implementation, a reduction in hospital length of stay was observed, with no apparent increase in complications or 30-day readmission rates. These findings suggest that ERPs may be applicable to selected trauma laparotomy patients, with the potential to improved clinical outcomes. Further large-scale studies are warranted to validate these results.

PMID:40059024 | DOI:10.1016/j.injury.2025.112238

Injury. 2025 Mar 3;56(4):112234. doi: 10.1016/j.injury.2025.112234. Online ahead of print.

ABSTRACT

INTRODUCTION: Assessment of mobility in orthopaedic trauma patients is commonly performed using the Lower Extremity Functional Assessment (LEFS). Computerized adaptive testing (CAT) utilizing the Patient-Reported Outcomes Measurement Information System (PROMIS) is an advanced method for assessing multiple aspects of patient-reported health and may provide an effective alternative for this purpose. The objective of this study was to correlate and psychometrically compare PROMIS (Mobility (MOB) and Physical Function (PF)) CATs to legacy mobility PROMs (Lower Extremity Functional Scale (LEFS)/ Short Musculoskeletal Function Assessment (SMFA)), and to evaluate factors associated with worse mobility.

PATIENTS AND METHODS: In this Cross-sectional study performed in a single Level-I trauma center, 123 patients were recruited who were treated for a lower-extremity fracture (October 1, 2021-July 1, 2023). Correlations (Pearson), known-group validity (Two-sample T test), reliability (Standard error (SE) and Cronbach's alpha), items and completion time, and floor/ceiling effects were assessed. Factors associated with PROMIS-MOB scores were also identified based on multivariable regression analysis.

RESULTS: PROMIS-MOB and LEFS/SMFA (0.75/0.86), PROMIS-PF and LEFS/SMFA (0.76/0.84), and both PROMIS-CATs (0.88) were highly correlated. Regarding know-group validity, all PROM scores were worse among patients with moderate-extreme pain. Only PROMIS-CATs scores were worse among older (≥65 years) and short-term follow-up (3≤months) patients. Reliability was very high for PROMIS-MOB (SE2.1), PROMIS-PF (SE2.0), LEFS (alpha0.97) and SMFA (apha0.97). Fewer items were needed for PROMIS-MOB (6) and PROMIS-PF (5) compared to LEFS (20) and SMFA (34). Completion time (mean seconds) of PROMIS-MOB (65) and PROMIS-PF (70) was less compared to LEFS (338) and SMFA (367) (p<0.001). Neither PROMIS-CATs nor LEFS/SMFA exhibited floor/ceiling effects. Advancing age, depression, pain intensity, shorter follow-up were associated with worse PROMIS-MOB scores.

CONCLUSION: PROMIS-MOB and PROMIS-PF CATs exhibited a strong correlation with the LEFS and SMFA, indicating that they offer the same information regarding mobility and general physical functioning. Nonetheless, CATs took less time to complete and were better able to detect (subtle) differences between certain groups than traditionally used PROMs. Given that both PROMIS-MOB and PROMIS-PF CATs were also highly correlated, it is questionable whether the more specific mobility CAT provides distinct information in lower extremity fracture patients.

LEVELS OF EVIDENCE: Diagnostic study, Level II.

PMID:40058156 | DOI:10.1016/j.injury.2025.112234