Injury. 2025 Feb 28;56(4):112231. doi: 10.1016/j.injury.2025.112231. Online ahead of print.

ABSTRACT

INTRODUCTION: There have been no published studies evaluating the impact of humeral stem length on humeral shaft periprosthetic fractures. We sought evaluate the differences in fracture patterns between periprosthetic fractures around a short stem and standard stem humeral implants.

MATERIALS AND METHODS: This is a retrospective cohort study. Patients sustaining a humeral shaft periprosthetic fracture around shoulder arthroplasty implants from December 2011 to January 2021 were identified using ICD-9/10 codes. Three upper extremity trained surgeons evaluated all radiographs assessing fracture location and configuration, as well as signs of stem stability before and after the fracture. They classified the fractures based on two classification schemes: Wright & Cofield, and the Unified Classification System (UCS), and they recorded their recommended treatment for each case based on fracture pattens and implant stability.

RESULTS: 76 patients with periprosthetic humeral shaft fractures were identified and divided into two groups: short stem (n=18) and standard stem (n=58). Patients with a short stem were more likely to be classified as having an unstable prosthesis after fracture (67% versus 33%, p=0.01). Additionally, the proposed plan for treatment was different between the two groups (p=0.004): more patients in the standard stem group were recommended open reduction internal fixation (50% vs. 33%) or non-operative treatment (17% vs. 0%), and more patients in the short stem group were recommended revision arthroplasty (50% vs. 29%).

CONCLUSION: Patients sustaining a periprosthetic fracture around a short implant may be more likely to have an unstable prosthesis compared to a standard stem, which may have an impact on treatment options.

LEVEL OF EVIDENCE: Prognosis Study, Level III.

PMID:40043641 | DOI:10.1016/j.injury.2025.112231

Injury. 2025 Feb 20;56(4):112225. doi: 10.1016/j.injury.2025.112225. Online ahead of print.

ABSTRACT

Lacerations rank as the most common paediatric injury that requires a physician evaluation. Glass is a frequent cause of such lacerations, however there is currently little to no information on this. Hence, this paper aims to describe the burden and characteristics of such injuries in Singapore. This study is a retrospective review of glass-related trauma presented to paediatric hospital KKH Emergency Department between 1st January 2017 and 4th July 2023. Data on patient and injury characteristics, as well as treatment plans were collected. 680 patients up to 18 years old (average 6.93) were included in the study. 420 (62 %) were male. The number of glass-related injuries were stable at about 100 per year from 2017 to 2023. 649 (95 %) cases were unintentional. 528 (78 %) injuries occurred indoors.159 (23 %) children had adult supervision at time of injury. A majority of 458 (67 %) injuries occurred during the weekday. Primary blunt injuries were the highest at 414 (61 %), followed by 230 (34 %) penetrating injuries. 317 (37 %) injuries occurred at the lower limb, 305 (36 %) at the upper limb, and 105 (12 %) at the face. 596 (87.6 %) patients had "None to mild" injuries, 31 (4.6 %) with "Moderate" injuries, and 53 (7.8 %) with "Severe" injuries. Glass doors led to 315 (46 %) cases, with glass shards and glass panels causing 85 (12.5 %) and 84 (12.5 %) cases respectively. 555 (82 %) of patients received definitive treatment in the Emergency Department and 74 (11 %) required surgery. The average duration of hospitalization of all patients is 0.36 days. 430 patients averaged 3.66 weeks of follow-up, while 247 were discharged immediately. 85 (13 %) patients required inpatient care. Only 1 patient required fluid resuscitation in the Emergency Department. Most glass injuries are unintentional, caused by glass doors, occur indoors and are, fortunately, mild cases.

PMID:40037263 | DOI:10.1016/j.injury.2025.112225

Injury. 2025 Feb 22;56(4):112227. doi: 10.1016/j.injury.2025.112227. Online ahead of print.

ABSTRACT

Interlocking screw backout is a significant complication of femoral nailing that may lead to pain, fixation failure, and need for reoperation. The risk for this is increased in osteoporotic bone or in cases of so-called "extreme nailing" when the articular segment is short, and fixation is limited. A newly developed retrograde femoral nailing system (DePuy Synthes RFN-Advanced™ Retrograde Femoral Nailing System (DePuy Synthes, Monument, CO)) was designed specifically to prevent this known failure mode and was recently approved for use within the United States. A preassembled polymer inlay at the distal portion of the nail (through which the distal interlocking screws are placed) is marketed as eliminating interfragmentary motion and screw toggle which can ultimately lead to screw backout. Despite this purposeful design, multiple surgeons at our Level I trauma center in the southeastern US have noted a relatively high occurrence of distal interlocking screw backout when compared to other nail designs used in the same time. We present a single institution retrospective review of placed retrograde femoral nails and their complications, particular loss of interlock bolt fixation and revision surgery in the DePuy Synthes RFN-A group (21.43 %), compared to other implant designs (5.41 %) during the initial implementation period at our institution.

PMID:40031117 | DOI:10.1016/j.injury.2025.112227

Injury. 2025 Feb 21;56(4):112226. doi: 10.1016/j.injury.2025.112226. Online ahead of print.

ABSTRACT

Diabetes mellitus is a chronic condition which disrupts bone homeostasis leading to impaired healing and profound complications in ankle fractures. Hyperglycaemia and chronic inflammation cause increased generation of advanced glycation end products and reactive oxygen species which ultimately drive osteoclastogenesis and increase bone resorption. Together with a lack of insulin signalling, these mechanisms compromise bone metabolism and increase the risk of complications in fracture healing. Diabetes is associated with comorbidities such as vasculopathy and neuropathy which further contribute to the risk of complications. The complications identified in diabetic patients with ankle fractures include non-union, malunion, infection, amputation, and mortality. Thus, careful consideration is needed when deciding between surgical and conservative treatment. This narrative review provides a synthesis of the literature covering the impact of diabetes on ankle fractures, considering their high prevalence in the UK.

PMID:40023923 | DOI:10.1016/j.injury.2025.112226

Injury. 2025 Feb 25;56(3):112228. doi: 10.1016/j.injury.2025.112228. Online ahead of print.

NO ABSTRACT

PMID:40022873 | DOI:10.1016/j.injury.2025.112228

Injury. 2025 Feb 20:112223. doi: 10.1016/j.injury.2025.112223. Online ahead of print.

ABSTRACT

OBJECTIVE: A case of traumatic strabismus was painted in two portraits of Franz Josias, Duke of Saxe-Coburg-Saalfeld (1697-1764). Both canvases are held by the Art Collection of Veste Coburg (Accession numbers: M.076 & M.363).

METHODS: Resorting to the "Guidelines for Iconodiagnosis", a careful comparison of the portraits of the Duke pre-dating an accident with those showing evidence of an ocular trauma afterwards, was performed. An analysis of the historical and biographical written sources was carried out as well.

RESULTS: At the age of 32 years, while playing battledore and shuttlecock (in French "jeu de volant", a forerunner of badminton), Duke Franz Josias sustained a traumatic left eye injury. This did not heal with time and was depicted in contemporary paintings of the Duke.

CONCLUSION: Combining both biographical and artistic sources, a diagnosis of post-traumatic strabismus due to injury of the left inferior rectus muscle was proposed with an Iconodiagnosis level of evidence II.

PMID:40021390 | DOI:10.1016/j.injury.2025.112223

Injury. 2025 Feb 20;56(4):112224. doi: 10.1016/j.injury.2025.112224. Online ahead of print.

ABSTRACT

INTRODUCTION: The soft tissue of the heel is weak, and calcaneal bone defects occur easily post-infection, resulting in the inability of paediatric patients to walk normally. Calcaneal reconstruction is challenging. We aimed to evaluate the methodology and clinical effects of the Ilizarov technique in the treatment of calcaneal infectious bone defects.

METHODS: We retrospectively analyzed the cases of 12 children with infectious calcaneal bone defects treated by the Ilizarov technique in our center from January 2018 to August 2022.Stump lengthening of the calcaneus was performed in nine cases. Due to severe calcaneus infection the calcaneus was removed, and talus lengthening was performed in three children. Two children were treated with drug-loaded spacer bone cement to control peripheral soft tissue infection before bone elongation could be performed, while the other ten cases underwent bone lengthening at one stage after radical debridement. Pain, foot function, self-care ability and hind foot function were evaluated using a Visual Analogue Scale (VAS), the Maryland Foot Score, Activity of Daily Living scale, and the American Orthopaedic Foot and Ankle Society retro ankle foot score.

RESULTS: In this cohort of 12 children, the time for bone lengthening ranged from 32 to 64 days (mean 41.75 ± 10.09 days), and the distance of bone lengthening was between 2.6 cm and 5.4 cm (mean 3.57 ± 0.86 cm). The inflammation indicators CRP, ESR, and IL-6 were significantly reduced after radical debridement (15.72 ± 3.09 vs 6.04 ± 1.28, 25.20 ± 2.72 vs 15.11 ± 1.56, 16.39 ± 3.75 vs 2.99 ± 1.08, respectively; p < 0.01). Bone reconstruction effectively reduced pain in the affected limb and significantly improved foot function, self-care ability, and hind foot function in these children. In four cases, external fixators were removed and an Achilles tendon lengthening operation was performed to further reconstruct calcaneal bone function. After surgical treatment, all the children in this cohort were able to return to normal life.

CONCLUSION: The Ilizarov technique for treating large infectious calcaneal bone defects and bone lengthening can effectively reconstruct the function of the calcaneal bone without significantly affecting the ankle joint.

PMID:40020515 | DOI:10.1016/j.injury.2025.112224

Injury. 2025 Feb 21:112222. doi: 10.1016/j.injury.2025.112222. Online ahead of print.

ABSTRACT

INTRODUCTION: Despite disproportionately bearing the global injury burden, low- and middle-income countries often lack emergency medical services(EMS). Equipping lay first responders(LFRs) with emergency medical dispatch(EMD) is a critical next step for formal EMS development. However, few context-appropriate mobile dispatch solutions are available for LFRs, and implementation feasibility and impact on response intervals are not well understood MATERIALS AND METHODS: A simulation-based feasibility trial assessed a novel EMD tool, previously used for shipping in resource-limited settings without formal addresses. Two cohorts of 10 non-EMD enabled LFRs trained in 2019 in Sierra Leone were recruited. 100 total simulations were launched in randomized order over 6 months(Cohort 1 distributed along 10 kms of highway(n = 50), Cohort 2 distributed across 24 square-kilometers of an urban setting(n = 50)). On-scene first aid skill performance was assessed under direct observation with a standardized patient actor using checklists. Participants were blinded to randomized dispatch timing/scenario to assess response intervals, replicating real-world conditions, and compared with two-sample t-tests. At six-month follow-up, participants were surveyed on tool ease-of-use and appropriateness, confidence, and ranked dispatch variable relative importance.

RESULTS: Median total response interval (initial notification to LFR arrival on scene) for Cohort 1 for linearly-plotted highway simulations was 6 mins 33 ss(IQR: 2m27 s; 10m48 s), while Cohort 2 for dispersed urban simulations was 6m41s(IQR:3m59 s;14m47 s) (p = 0.720). Median distance between simulated emergency and LFR at the time of notification acceptance=1.675 km(IQR:1.13 km;2.47 km) and 1.73 km(IQR:0.82 km;2.28 km). Mean completion percentage of all discrete first aid steps across all 10 simulation scenario types for Cohort 1 = 89.8 %(IQR: 80 %;100 %) and Cohort 2 = 94.9 %(IQR: 88.89 %;100 %) (p = 0.017). Mean confidence was 9.4/10(median=10) and 9.5/10(median=10)(p = 0.889). 75 % of LFRs (15/20) used the compass feature for navigation while 25 % used turn-by-turn directions (5/20). 70 % LFRs (14/20) reported no unexpected data costs. Emergency location was considered the most important dispatch variable factor, followed by nature/severity of injury.

DISCUSSION: A novel mobile navigation tool for EMD accurately dispatches LFRs to simulated emergency incidents across linear/dispersed settings without significant difference in response interval. Equipping LFRs with EMD tools may facilitate efficient dispatch in resource-limited settings to trauma while expanding emergency care access, meriting further study.

PMID:40016018 | DOI:10.1016/j.injury.2025.112222

Injury. 2025 Jan 31;56(3):112179. doi: 10.1016/j.injury.2025.112179. Online ahead of print.

ABSTRACT

INTRODUCTION: The older population, especially centenarians, is growing. Hip fractures significantly affect this demographic; however, studies on centenarians are limited. This study aimed to compare hip fracture mortality and associated risk factors between centenarians, nonagenarians, and octogenarians with focus on centenarians.

METHODS: Data from the Korean Health Insurance Review and Assessment database were retrospectively analyzed. Individuals aged ≥ 80 years with an ICD-10 diagnosis code (S72) and procedure codes indicative of hip fracture surgery between 2012 and 2022 were included. The primary outcome was mortality at 1, 3, 6 months, and 1 year postoperatively. The secondary outcomes included the prevalence of comorbidities and postoperative complications.

RESULTS: 131,746 patients were included (106,244 [80.6 %] octogenarians, 24,842 [18.9 %] nonagenarians, and 660 [0.5 %] centenarians). Centenarians had lower Charlson Comorbidity Index than that of nonagenarians and octogenarians (4.4, 4.9, and 5.7, respectively; P < 0.000). However, perioperative medical complications such as acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), pneumonia, sepsis, and urinary tract infection increased linearly with age, significantly affecting centenarians. Mortality rates were highest in centenarians, especially within the first 3 postoperative months. The risk factors for 3-month mortality included the male sex (odds ratio [OR] 1.79, 95 % confidence interval [CI] 1.01-3.12, P = 0.046), and heart failure (OR 1.72, 95 % CI 1.07-2.79, P = 0.026) preoperatively, and AKI (OR 3.92, 95 % CI 1.97-7.82, P < 0.000), ARDS (OR 2.92, 95 % CI 1.04-8.23, P = 0.04), pneumonia (OR 1.91, 95 % CI 1.11-3.29, P = 0.02), and sepsis (OR 10.01, 95 % CI 3.52-28.45, P < 0.000) postoperatively.

CONCLUSION: Despite having fewer comorbidities, centenarians had the highest postoperative mortality, primarily due to organ dysfunction such as pneumonia, AKI, ARDS, and sepsis, rather than vascular events. Tailored medical management strategies focusing on these complications are crucial for improving centenarians outcomes.

PMID:39985925 | DOI:10.1016/j.injury.2025.112179

Injury. 2025 Feb 15;56(3):112215. doi: 10.1016/j.injury.2025.112215. Online ahead of print.

ABSTRACT

BACKGROUND: Cefazolin is the primary antibiotic for surgical prophylaxis in orthopedic procedures. The cessation of cefazolin supply in approximately 60 % of Japanese hospitals from 2019 to 2020 provided an opportunity to evaluate the effectiveness of alternative beta-lactams for preventing surgical site infection (SSI). Given the global potential for antibiotics shortages, confirming the effectiveness of alternative beta-lactams is critical.

PURPOSE: This study aims to evaluate the differences in risk of reoperation for SSI between cefazolin and alternative beta-lactams in patients undergoing lower extremity fracture surgeries.

METHODS: We emulated a target trial to compare the effectiveness of cefazolin with alternative beta-lactams-specifically broad-spectrum penicillins and cephalosporins-in preventing SSI using a Japanese hospital administrative database provided by JMDC Inc. We included patients undergoing initial open reduction and internal fixation for closed lower extremity fractures between March 1, 2019, and February 29, 2020. The outcome was reoperation for SSI within 30 days after surgery. Risks were estimated using pooled logistic regression with adjustment for confounders via inverse probability weighting. Sensitivity analyses extended the follow-up period to 90 and 365 days.

RESULTS: Of the 16,602 patients analyzed, 35 patients (0.30 %) in the cefazolin group (11,538 patients) and 16 patients (0.32 %) in the alternative beta-lactam group (5,064 patients) underwent reoperation for SSI within 30 days. The estimated 30-day risk was 0.31 % in the cefazolin group and 0.37 % in the alternative beta-lactam group, resulting in a risk difference of -0.06 % (95 % confidence interval [CI], -0.33 to 0.14) and a risk ratio of 0.82 (95 % CI, 0.50 to 1.52). In sensitivity analyses, the estimated 90-day risk was 0.67 % in the cefazolin group and 0.57 % in the alternative beta-lactam group, with a risk difference of 0.10 % (95 % CI, -0.15 to 0.32) and a risk ratio of 1.19 (95 % CI, 0.80 to 1.62). The 365-day risk was 1.02 % and 0.90 %, respectively, with a risk difference of 0.12 % (95 % CI, -0.29 to 0.39) and a risk ratio of 1.13 (95 % CI, 0.78 to 1.51).

CONCLUSIONS: In surgeries for lower extremity fractures, substituting cefazolin with alternative beta-lactams did not result in substantial differences in the risk of reoperation for SSI.

PMID:39983535 | DOI:10.1016/j.injury.2025.112215

Injury. 2025 Feb 15;56(3):112217. doi: 10.1016/j.injury.2025.112217. Online ahead of print.

ABSTRACT

INTRODUCTION: Fragility fractures of the proximal femur are common injuries with significant morbidity and mortality. The use of direct oral anticoagulant (DOAC) medications is increasing among the elderly and is associated with perioperative bleeding-related complications. The primary aim of this study was to examine how DOAC use affects surgical timing and postoperative hematologic complications in patients treated operatively for fragility fractures of the proximal femur. The effect of an institutional tranexamic acid (TXA) protocol implemented during the study period was investigated as a secondary aim.

MATERIALS AND METHODS: This was a retrospective analysis performed at a Level I trauma center. Between March 1, 2018 and April 1, 2022, 746 patients age 50 years and older who underwent surgical treatment for a fragility fracture of the femoral neck, intertrochanteric, or subtrochanteric region of the proximal femur (AO/OTA 31A, 31B, 32) and who were either on no chemical anticoagulation, warfarin, or a DOAC at the time of injury were included. The primary outcomes were time to operating room (TTOR), postoperative transfusion, 30-day venous thromboembolism (VTE), and 30-day hospital readmission. Multivariable logistic regression modeling was used to analyze the effect of anticoagulant, TXA use, and TTOR on these outcomes.

RESULTS: TTOR was increased for patients on warfarin (38.3 ± 26.1 h) or a DOAC (46.4 ± 23.4 h) compared to patients not on anticoagulation (28.0 ± 19.0 h) (p < 0.001). There was no significant difference in transfusion rates among patients not on anticoagulants (31.8 %), warfarin (43.4 %), or a DOAC (29.6 %). Multivariable regression showed a decrease in transfusion rate (OR 0.35, 95 % CI 0.23-0.53) and 30-day readmission (OR 0.31, 95 % CI 0.15-0.61) for intravenous (IV) TXA.

CONCLUSIONS: DOAC use was associated with an increase in TTOR without increased rates of transfusion, VTE, or hospital readmission in patients with fragility fractures of the proximal femur. Intravenous TXA was associated with reduced postoperative transfusion and 30-day readmission.

PMID:39983534 | DOI:10.1016/j.injury.2025.112217

Injury. 2025 Feb 15;56(3):112219. doi: 10.1016/j.injury.2025.112219. Online ahead of print.

ABSTRACT

BACKGROUND: Osteoporosis screening guidelines recommend bone mineral density (BMD) testing following fragility fractures. Nevertheless, previous studies have demonstrated low rates of osteoporosis screening. Diagnosis and treatment of osteoporosis is essential for prevention of future fractures, however not much is known about the factors associated with receiving BMD testing in this patient population. The purpose of this study was to evaluate the prevalence, timing, and predictors of BMD testing following distal radius fractures (DRF) in menopausal women.

METHODS: We queried a national insurance database to identify menopausal women aged 45-64 years with a DRF between years 2013 and 2020. The rate of BMD testing within 1 year of injury was calculated. Multivariable logistic regression analysis was used to evaluate the effect of patient- and injury-related variables on the likelihood of undergoing BMD testing following DRF.

RESULTS: Among 31,728 patients meeting inclusion criteria (mean ± SD age: 57.5 ± 4.3), 3,886 (12.2 %) received a BMD test within 1 year following DRF. The rate of BMD tests decreased with the highest rate of 14.5 % in 2015 and the lowest rate of 10.5 % in 2020. Mean time from DRF to BMD testing was 143 ± 102 days. Patients aged 60-64 had the highest adjusted odds of receiving BMD testing (OR 2.85 [95 % CI: 2.26 to 3.64]). Factors associated with increased likelihood of BMD testing included surgical intervention (OR 1.38 [1.28-1.48]), rheumatoid arthritis (OR 1.22 [1.06-1.40]), osteoarthritis (OR 1.28 [1.19-1.37]), breast cancer (OR 1.35 [1.16-1.56]), and vitamin D deficiency (OR 1.29 [1.17-1.43]). Factors associated with decreased likelihood of testing included tobacco use (OR 0.90 [0.84-0.97]), patients with Medicaid (OR 0.73 [0.61-0.86]) or Medicare (OR 0.76 [0.65-0.88]) insurance, and living in Southern (OR 0.67 [0.62-0.73]) or Western (OR 0.69 [0.62-0.77]) regions of the United States. Obesity, diabetes, renal disease, and early menopause were not associated with BMD testing.

CONCLUSIONS: Despite guidelines recommending BMD testing after low-energy fractures, rates of BMD testing were low and decreased among menopausal women with DRF. Mean time to BMD testing was 4.7 months, indicating substantial delays in workup. Known risk factors for osteoporosis did not reliably predict likelihood of BMD testing.

LEVEL OF EVIDENCE: Level III, prognostic.

PMID:39983533 | DOI:10.1016/j.injury.2025.112219

Injury. 2025 Feb 9;56(3):112206. doi: 10.1016/j.injury.2025.112206. Online ahead of print.

ABSTRACT

BACKGROUND: Fragility fractures of the pelvis (FFP) present a growing challenge in aging populations. However, standardized classifications and treatment guidelines remain scarce.

OBJECTIVE: This scoping review examines the application of fracture classifications, treatment strategies, and outcome evaluations for FFP, identifying gaps in the literature, and suggesting directions for future research.

METHODS: A systematic search of multiple electronic databases yielded 117 studies discussing FFP names, classifications, treatment approaches, and outcomes. Data extraction focused on study characteristics, classification systems, treatment details, outcomes, and follow-up periods. Residual analysis using the Chi-square test assessed statistical associations and underrepresentation.

RESULTS: The FFP classification was the most common (51.3%), with additional treatment indicators focused on immobility (44.4%) and pain assessment (using the Visual Analog Scale [VAS] or Numeric Rating Scale [NRS], 37.6%), consistent with existing guidelines. In contrast, the sacral insufficient fractures were statistically associated with pain indications but lacked corresponding classification application. Initial management typically involved conservative or observation period. Regarding the management indications and outcomes, surgical interventions were categorized into osteosynthesis and sacroplasty. Outcome evaluations often incorporated mobility and functional status (59.0%), hospitalization length (49.6%), mortality rates (41.0%), and post-treatment living conditions (41.0%). Patient recovery was assessed through VAS scores (59.0%) and Activities of Daily Living Patient-Reported Outcomes (ADL-PROs, 34.2%). However, inconsistencies in standardized outcomes, particularly in sacroplasty studies, hinder comparative analysis.

CONCLUSION: FFP classifications, along with pain and mobility assessments, were frequently applied as management indicators for FFP. Standardizing treatment indications and establishing consistent outcome measures, including the evidenced gap treatments (sacral insufficient fracture and cement augmentation), could significantly improve comparability across studies.

PMID:39983532 | DOI:10.1016/j.injury.2025.112206

Injury. 2025 Feb 16;56(3):112221. doi: 10.1016/j.injury.2025.112221. Online ahead of print.

ABSTRACT

BACKGROUND: Road injuries remain a significant global health issue, contributing to a high burden of mortality and disability, particularly in low- and middle-income countries. Understanding the global trends in incidence, mortality, and Years Lived with Disability (YLDs) due to road injuries is essential for developing effective prevention strategies.

METHODS: We used data from the Global Burden of Disease (GBD) 2021 to analyze road injury trends from 1990 to 2021. Age-standardized incidence rates (ASIR), mortality rates (ASMR), and YLDs were calculated across different socio-demographic index (SDI) regions. Trends were assessed using the Estimated Annual Percentage Change (EAPC), and disparities by age, sex, and cause of injury were evaluated.

RESULTS: From 1990 to 2021, the global ASIR, ASMR, and YLDs due to road injuries showed a declining trend. However, road injury cases and deaths increased in low and middle-SDI regions, while declining in high-SDI regions. In 2021, the highest ASIR was observed in high-SDI regions (851.75 per 100,000 population), while low-SDI regions experienced the highest mortality rates (22.6 per 100,000 population). Males, particularly those aged 15-49 years, bore the greatest burden of road injuries, accounting for over 60% of YLDs globally. Pedestrian and motorcycle-related injuries were predominant in low-SDI regions.

CONCLUSION: While global road safety interventions have reduced the burden of road injuries, substantial disparities remain between SDI regions. Targeted interventions are needed to address the high burden of road injuries in low-SDI regions, focusing on improving infrastructure and healthcare access.

PMID:39978035 | DOI:10.1016/j.injury.2025.112221

Injury. 2025 Jan 27;56(3):112166. doi: 10.1016/j.injury.2025.112166. Online ahead of print.

ABSTRACT

Despite substantial progress in road safety, road traffic fatalities (RTFs) continue to be a persistent issue in Australia. This study aims to forecast RTFs trends up to 2050 by analyzing factors such as geographic location, age, gender, speed limits, and time of occurrence. Utilizing historical data from 1989 to 2024, fatalities were categorized by road user type, demographics, and day of the week. The Facebook Prophet time series model, incorporating categorical variables like region, age, and speed limits, was employed to predict future trends. The analysis reveals significant regional disparities in fatality reduction rates, with some areas lagging others. Gender-specific forecasts indicate a sharper decline in male fatalities compared to females, while projections highlight persistent risks for older drivers. Additionally, highways with higher speed limits are expected to see a substantial decrease in fatalities. These insights emphasize the need for targeted interventions in areas with slower reductions and high-risk demographic groups, aiding policymakers in refining safety measures, enforcing speed limits, and enhancing public awareness campaigns.

PMID:39970494 | DOI:10.1016/j.injury.2025.112166

Injury. 2025 Feb 10:112214. doi: 10.1016/j.injury.2025.112214. Online ahead of print.

ABSTRACT

BACKGROUND: Houselessness is associated with increased mortality and unmet health needs. Current understanding of traumatic injury in houseless patients is limited.

METHODS: This is a retrospective matched cohort study among houseless and housed adults, admitted to an urban, safety net, level I trauma center from 1/1/2018-12/31/2021. Houseless patients were matched with their housed counterparts 1:2 based on age, sex, injury severity score (ISS) and nature of injury. The primary outcome was in-hospital adverse events. Secondary outcomes included hospital length of stay (LOS), outpatient follow-up, emergency department (ED) utilization post-injury, and readmission. Conditional multivariable regression was used to determine associations between the exposure and outcomes.

RESULTS: 1413 patients were included; 471 houseless patients and 942 matched controls. Median [IQR] age was 42 years [31-58] and median [IQR] ISS was 9 [5-13] for all patients. About 30 % of traumatic injuries were violent in nature. Median [IQR] total LOS was longer for houseless patients (4.4 days [2.0-8.3] vs. 3.1 days [1.4-6.5], p < 0.001). Houseless patients were more frequently admitted to the ICU (5 % versus 3 %, p = 0.045). The rate of any in-hospital adverse event was similar (houseless 17 % vs. housed 16 %, p = 0.537). Adjusting for age, sex, language, insurance, ISS, nature of injury, injury mechanism, ICU admission, and operative intervention, houselessness was inversely associated with outpatient follow-up (OR 0.60, 95 % CI 0.46-0.79) and positively associated with ED representation (OR 2.49, 95 % CI 1.64-3.78) and hospital readmission (OR 4.35, 95 % CI 3.19-5.92).

CONCLUSIONS: Housing status was not associated with increased in-hospital morbidity or mortality in trauma patients in a single institution cohort of trauma patients. Unhoused patients had lower odds of completing outpatient injury-specific follow-up and higher odds of utilizing the ED within 30 days of discharge. These findings highlight gaps in post-discharge care coordination and underscore opportunities to improve discharge services for this population.

PMID:39966000 | DOI:10.1016/j.injury.2025.112214

Injury. 2025 Feb 12;56(3):112213. doi: 10.1016/j.injury.2025.112213. Online ahead of print.

ABSTRACT

Foot and ankle soft tissue defects with exposed bone pose significant challenges in wound healing and patient satisfaction OBJECTIVE: The study aims to assess the impact of nursing care quality and patient satisfaction on optimizing outcomes for complex foot and ankles injuries, focusing on the timing of rh-FGF administration after reconstructive surgery METHODS: This study included eighteen patients (15 males and 3 females) with traumatic foot and ankle soft tissue defects and exposed bone wounds, treated between January 2021 and December 2022. Patients were randomly assigned to three groups, underwent reconstructive surgery, and received rh-bFGF at varying times postoperatively. Key outcomes included wound healing time, hospital stay duration, satisfaction with nursing care scale, American Orthopedic Foot and Ankle Society (AOFAS) score, and Visual Analogue Scale for pain. All patients were followed for at least three months RESULTS: The study population had an average age of 41.1 years, with a range from 16 to 74 years. Findings indicated an average hospital stay of 17 days and a corresponding wound healing time of 17 days. At three months post-operation, the average American Orthopedic Foot and Ankle Society (AOFAS) score was 88. A notable 88.9 % of patients expressed satisfaction with the attentiveness of nursing staff and the privacy afforded to them. Furthermore, 84.3 % rated the nurses' competence positively, and 83.3 % appreciated the support provided to family and friends, along with personalized care and nurses' expertise in patient management. The results demonstrated a consistent trend of improvement in all assessed outcomes across the three treatment groups. Patients in Group 1, who received rh-bFGF one day after surgery, demonstrated the most favorable outcomes. This was followed by Group 3, which received rh-bFGF until ischemic changes were noted. In contrast, Group 2, which received rh-bFGF once inflammatory granulation had subsided, exhibited the least improvement CONCLUSION: The results of this study highlight the crucial role of timing in the administration of rh-bFGF for optimizing soft tissue repair in patients with foot and ankle defects. Timely application of rh-bFGF post-surgery is essential for achieving favorable patient outcomes, improving patient satisfaction with nursing care, and facilitating faster recovery.

PMID:39965533 | DOI:10.1016/j.injury.2025.112213

Injury. 2025 Feb 12;56(3):112212. doi: 10.1016/j.injury.2025.112212. Online ahead of print.

ABSTRACT

INTRODUCTION: Achilles tendon rupture (ATR) carries a high risk of venous thrombo-embolism (VTE) whether the injury is managed surgically or non-operatively. This study reports symptomatic VTE rate following ATR. The influence of patient demographics, treatment type and use of chemical thromboprophylaxis is examined.

MATERIALS AND METHODS: Observational cohort study. The data is from a multi-centre, prospective, national audit of patients from 68 participating United Kingdom centres. Data was prospectively collected from hospital records. The study was conducted between June and November 2022, with a 3-month follow up.

RESULTS: Of 11,363 participants in the National Audit, 9.5 % (n = 1084) had experienced an ATR. Management strategies included both non-surgical (74 %) and surgical (26 %). Following ATR, the VTE rate was 3.69 % (n = 40) compared to 0.57 % (n = 59) for other foot and ankle surgeries. Participants who developed symptomatic VTE after ATR were older than those who did not (mean age 54 years (95 %CI 50.5 - 54.7) vs 48 years (95 %CI 47.3 - 49.1)). There was no significant difference in VTE events due to participant sex, ethnicity or number of comorbidities. Differences in treatment regimen, such as weight-bearing status and immobilisation strategy, showed no significant difference in symptomatic VTE events between groups.

CONCLUSION: After ATR, patients are 6.5-times more likely to experience symptomatic VTE than those recovering from surgery for other foot and ankle pathology. There was no significant difference in symptomatic VTE rate after ATR with specific chemical prophylaxis or early mobilisation strategies.

PMID:39961162 | DOI:10.1016/j.injury.2025.112212

Injury. 2025 Feb 7;56(3):112205. doi: 10.1016/j.injury.2025.112205. Online ahead of print.

ABSTRACT

OBJECTIVES: TAD > 25 mm is a risk factor for cut-out in intramedullary nailing. Less attention has been given to the risk factors for central cut-through and the possible outcomes of TAD <10 mm. Furthermore, the risk of cut-through depending on minimum depth on either anterior-posterior (AP) or lateral views has not been explored. The goal of this study is to outline the parameters that increase risk of cut-through in intertrochanteric hip fractures.

METHODS: A retrospective review of 2128 intertrochanteric hip fractures admitted to a single level 1 academic trauma center from 2014 - 2023 was conducted. Variables included patient and operative characteristics, fracture fixation device, fracture type based on OTA/AO 2018 classification, TAD, neck-shaft angle and radiographic and clinical outcomes.

RESULTS: TAD <10 millimeters carried a significantly higher risk for lag screw and blade cut-through. Cut-through risk increased significantly when either AP or lateral apex-to-center distance was <4 millimeters, including when comparing fracture reduction quality for a cohort including sliding hip screws, lag screws and blades. Cut-out complications in this cohort only occurred with a TAD >10 mm and was significantly more likely to occur with TAD >25 mm, similar to prior studies.

CONCLUSION: TAD optimization between 10 and 25 mm reduces risk of both cut-out and cut-through and maintenance of 4 mm of distance between apex-to-center distance may help decrease the risk of cut-through complications.

PMID:39954635 | DOI:10.1016/j.injury.2025.112205

Injury. 2025 Feb 9;56(3):112211. doi: 10.1016/j.injury.2025.112211. Online ahead of print.

ABSTRACT

INTRODUCTION: Muscle weakness is among the most common motor deficits in individuals with spinal cord injury (SCI). Acute intermittent hypoxia (AIH) has been used to improve motor function by facilitating neuroplasticity. The purpose of this systematic review is to explore the impacts of AIH on muscle strength in individuals with SCI, identify who would most likely respond well to the intervention, and determine the optimal therapeutic protocol.

METHODS: Relevant literature was explored in "PubMed, MEDLINE, The Cochrane Library, Scopus, PEDro, and Web of Science" databases until October 2024. Randomized trials that involved SCI patients who underwent AIH, compared with controls, and assessed muscle strength were included in this review. The methodological quality was assessed using the "Physiotherapy Evidence Database (PEDro)" scale. The effect sizes were calculated using Cohen's d.

RESULTS: Of 502 studies, seven studies met the eligibility criteria, and the sample sizes ranged from 12 to 28 participants across the included studies. In total, 146 SCI patients (mean age 46.76 years; 88 % male) were included in this systematic review. The PEDro scores of the studies included varied between 5 and 8, with a median score of 8.

CONCLUSIONS: AIH is a promising therapeutic modality for enhancing muscle strength post-SCI, specifically in patients with motor-incomplete injuries. Based on good quality studies, delivering AIH independently or in combination with other treatments for 15 short (60-90 s) episodes of hypoxic exposure (Oxygen = 9 %) alternating with 15 (60-90 s) normoxic episodes (Oxygen = 21 %), across one or more sessions, could yield meaningful outcomes. Nevertheless, the evidence is limited by treatment protocol variations, small sample sizes, and a lack of standardization in combining AIH with other treatments. Therefore, further studies with larger sample sizes, more diverse populations, and standardized treatment protocols are strongly needed to verify our findings. Future studies should also address the potential bias, examine the long-term effects, and investigate underlying mechanisms to provide more generalized evidence.

PMID:39951963 | DOI:10.1016/j.injury.2025.112211